In Vitro Systems for Toxicity Evaluation of Microbial Volatile Organic Compounds on Humans: Current Status and Trends

dc.contributor.authorCerimi, Kustrim
dc.contributor.authorJäckel, Udo
dc.contributor.authorMeyer, Vera
dc.contributor.authorDaher, Ugarit
dc.contributor.authorReinert, Jessica
dc.contributor.authorKlar, Stefanie
dc.date.accessioned2022-02-14T14:17:31Z
dc.date.available2022-02-14T14:17:31Z
dc.date.issued2022-01-13
dc.date.updated2022-02-09T01:45:03Z
dc.description.abstractMicrobial volatile organic compounds (mVOC) are metabolic products and by-products of bacteria and fungi. They play an important role in the biosphere: They are responsible for inter- and intra-species communication and can positively or negatively affect growth in plants. But they can also cause discomfort and disease symptoms in humans. Although a link between mVOCs and respiratory health symptoms in humans has been demonstrated by numerous studies, standardized test systems for evaluating the toxicity of mVOCs are currently not available. Also, mVOCs are not considered systematically at regulatory level. We therefore performed a literature survey of existing in vitro exposure systems and lung models in order to summarize the state-of-the-art and discuss their suitability for understanding the potential toxic effects of mVOCs on human health. We present a review of submerged cultivation, air-liquid-interface (ALI), spheroids and organoids as well as multi-organ approaches and compare their advantages and disadvantages. Furthermore, we discuss the limitations of mVOC fingerprinting. However, given the most recent developments in the field, we expect that there will soon be adequate models of the human respiratory tract and its response to mVOCs.en
dc.identifier.eissn2309-608X
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/16363
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-15139
dc.language.isoenen
dc.rightsLicensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc570 Biowissenschaften; Biologiede
dc.subject.otherrespiratory healthen
dc.subject.otherIn vitro toxicologyen
dc.subject.othermicrobial volatile organic compoundsen
dc.subject.otherin vitro exposure systemen
dc.subject.otherorganoidsen
dc.subject.otherfingerprintingen
dc.titleIn Vitro Systems for Toxicity Evaluation of Microbial Volatile Organic Compounds on Humans: Current Status and Trendsen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber75en
dcterms.bibliographicCitation.doi10.3390/jof8010075en
dcterms.bibliographicCitation.issue1en
dcterms.bibliographicCitation.journaltitleJournal of Fungien
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume8en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften>Inst. Biotechnologie>FG Angewandte und Molekulare Mikrobiologiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Angewandte und Molekulare Mikrobiologiede
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
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