Zinc and Sepsis

dc.contributor.authorAlker, Wiebke
dc.contributor.authorHaase, Hajo
dc.date.accessioned2019-08-29T11:59:47Z
dc.date.available2019-08-29T11:59:47Z
dc.date.issued2018-07-27
dc.date.updated2019-08-01T09:00:38Z
dc.description.abstractSepsis, defined as a “life-threatening organ dysfunction caused by a dysregulated host-response to infection” is a major health issue worldwide and still lacks a fully elucidated pathobiology and uniform diagnostic tests. The trace element zinc is known to be crucial to ensure an appropriate immune response. During sepsis a redistribution of zinc from serum into the liver has been observed and several studies imply a correlation between zinc and sepsis outcome. Therefore the alterations of zinc concentrations in different tissues might serve as one part of the host’s defense mechanism against pathogens during sepsis by diverse mechanisms. It has been suggested that zinc is involved in nutritional immunity, acts as a hepatoprotective agent, or a differentiation signal for innate immune cells, or supports the synthesis of acute phase proteins. Further knowledge about these events could help in the evaluation of how zinc could be optimally applied to improve treatment of septic patients. Moreover, the changes in zinc homeostasis are substantial and correlate with the severity of the disease, suggesting that zinc might also be useful as a diagnostic marker for evaluating the severity and predicting the outcome of sepsis.en
dc.description.sponsorshipDFG, 316442145, FOR 2558: Interaktionen von essenziellen Spurenelementen in gesunden und erkrankten älteren Menschen (TraceAge)en
dc.description.sponsorshipDFG, 316442145, Immunmodulatorische Effekte von Spurenelementkombinationen auf das alternde Immunsystemen
dc.identifier.eissn2072-6643
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/9926
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-8936
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc610 Medizin und Gesundheitde
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.subject.otherzincen
dc.subject.othersepsisen
dc.subject.otherbiomarkeren
dc.subject.othersupplementationen
dc.subject.otherhomeostasisen
dc.titleZinc and Sepsisen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber976en
dcterms.bibliographicCitation.doi10.3390/nu10080976en
dcterms.bibliographicCitation.issue8en
dcterms.bibliographicCitation.journaltitleNutrientsen
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume10en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften>Inst. Lebensmitteltechnologie und Lebensmittelchemie>FG Lebensmittelchemie und Toxikologiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Lebensmittelchemie und Toxikologiede
tub.affiliation.instituteInst. Lebensmitteltechnologie und Lebensmittelchemiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
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