Rethinking ‘immunological memory’: Local and systemic immunity provided by bone marrow‐resident memory cells

dc.contributor.authorMcGrath, Mairi Anne
dc.contributor.authorDong, Jun
dc.contributor.authorMashreghi, Mir‐Farzin
dc.contributor.authorChang, Hyun‐Dong
dc.contributor.authorRadbruch, Andreas
dc.date.accessioned2023-05-17T07:39:14Z
dc.date.available2023-05-17T07:39:14Z
dc.date.issued2022-11-14
dc.date.updated2023-04-19T22:42:51Z
dc.description.abstractIt has been 25 years since we first described long‐lived memory plasma cells of the bone marrow, 13 years since we identified bone marrow resident memory T cells and 2 years since we showed that the bone marrow is also a preferred location of resident memory B cells. The bone marrow is increasingly recognized as a fundamental component of long‐lasting immunological memory, not only providing protective immunity but also fuelling chronic inflammation. We now understand that the bone marrow functions as the ‘backbone’ of immunological memory, hosting the memory plasma cells which provide not only humoral immunity but also memory B and T cells, which constitute ‘reactive memory’. This knowledge now allows us to define true cellular ‘correlates of protection’ for systemic immunity, its quality and duration, as induced by infection and vaccination, something that has never been more important given the recent SARS‐CoV‐2 pandemic. While memory plasma cells of the bone marrow indicate long‐lasting humoral protection, memory T (and B) cells mobilized into the blood in secondary immune reactions indicate the strength of reactive memory. In this review, we have contextualized many of our own findings from the last two decades that have contributed to our understanding of how bone marrow‐resident memory cells provide local and systemic immunity.en
dc.description.sponsorshipDFG, 389687267, Kompartimentalisierung, Aufrechterhaltung und Reaktivierung humaner Gedächtnis-T-Lymphozyten aus Knochenmark und peripherem Blut
dc.description.sponsorshipDFG, 215346292, TRR 130: B-Zellen: Immunität und Autoimmunität
dc.description.sponsorshipDFG, 375876048, TRR 241: Immun-Epitheliale Signalwege bei chronisch entzündlichen Darmerkrankungen
dc.description.sponsorshipEC/FP7/268987/EU/Protective and pathogenic immunological memory and its organisation by stroma cells/IMMEMO
dc.identifier.eissn1365-3083
dc.identifier.issn0300-9475
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/18877
dc.identifier.urihttps://doi.org/10.14279/depositonce-17682
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.subject.otherbone marrow
dc.subject.otherimmunological memory
dc.subject.othertissue‐resident
dc.titleRethinking ‘immunological memory’: Local and systemic immunity provided by bone marrow‐resident memory cellsen
dc.typeArticle
dc.type.versionpublishedVersion
dcterms.bibliographicCitation.articlenumbere13232
dcterms.bibliographicCitation.doi10.1111/sji.13232
dcterms.bibliographicCitation.issue6
dcterms.bibliographicCitation.journaltitleScandinavian Journal of Immunologyen
dcterms.bibliographicCitation.originalpublishernameWiley
dcterms.bibliographicCitation.originalpublisherplaceNew York, NY
dcterms.bibliographicCitation.volume96
dcterms.rightsHolder.referenceCreative-Commons-Lizenz
tub.accessrights.dnbfree
tub.affiliationFak. 3 Prozesswissenschaften::Inst. Biotechnologie::FG Zytometrie
tub.publisher.universityorinstitutionTechnische Universität Berlin

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