An Individual Patient's “Body” on Chips—How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approach

dc.contributor.authorMarx, Uwe
dc.contributor.authorAccastelli, Enrico
dc.contributor.authorDavid, Rhiannon
dc.contributor.authorErfurth, Hendrik
dc.contributor.authorKoenig, Leopold
dc.contributor.authorLauster, Roland
dc.contributor.authorRamme, Anja Patricia
dc.contributor.authorReinke, Petra
dc.contributor.authorVolk, Hans-Dieter
dc.contributor.authorWinter, Annika
dc.contributor.authorDehne, Eva-Maria
dc.date.accessioned2021-09-29T10:01:50Z
dc.date.available2021-09-29T10:01:50Z
dc.date.issued2021-09-13
dc.date.updated2021-09-27T07:01:40Z
dc.description.abstractThe first concepts for reproducing human systemic organismal biology in vitro were developed over 12 years ago. Such concepts, then called human- or body-on-a-chip, claimed that microphysiological systems would become the relevant technology platform emulating the physiology and morphology of human organisms at the smallest biologically acceptable scale in vitro and, therefore, would enable the selection of personalized therapies for any patient at unprecedented precision. Meanwhile, the first human organoids—stem cell-derived complex three-dimensional organ models that expand and self-organize in vitro—have proven that in vitro self-assembly of minute premature human organ-like structures is feasible, once the respective stimuli of ontogenesis are provided to human stem cells. Such premature organoids can precisely reflect a number of distinct physiological and pathophysiological features of their respective counterparts in the human body. We now develop the human-on-a-chip concepts of the past into an organismoid theory. We describe the current concept and principles to create a series of organismoids—minute, mindless and emotion-free physiological in vitro equivalents of an individual's mature human body—by an artificially short process of morphogenetic self-assembly mimicking an individual's ontogenesis from egg cell to sexually mature organism. Subsequently, we provide the concept and principles to maintain such an individual's set of organismoids at a self-sustained functional healthy homeostasis over very long time frames in vitro. Principles how to perturb a subset of healthy organismoids by means of the natural or artificial induction of diseases are enrolled to emulate an individual's disease process. Finally, we discuss using such series of healthy and perturbed organismoids in predictively selecting, scheduling and dosing an individual patient's personalized therapy or medicine precisely. The potential impact of the organismoid theory on our healthcare system generally and the rapid adoption of disruptive personalized T-cell therapies particularly is highlighted.en
dc.description.sponsorshipEC/H2020/820292/EU/RESTORE Health by Advanced Therapies (Advanced Therapy Medicinal Products and Biologized Medical Devices) – ALL for Advanced Therapies – with Passion – For Patients/RESTOREen
dc.identifier.eissn2296-858X
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/13646
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-12434
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc610 Medizin und Gesundheitde
dc.subject.otherorganismoiden
dc.subject.otherorgan-on-chipen
dc.subject.othermicrophysiological systemsen
dc.subject.otherreal world dataen
dc.subject.otherimmune-oncologyen
dc.subject.otheradvanced therapiesen
dc.subject.otherorganoiden
dc.subject.otherpatient-on-chipen
dc.titleAn Individual Patient's “Body” on Chips—How Organismoid Theory Can Translate Into Your Personal Precision Therapy Approachen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber728866en
dcterms.bibliographicCitation.doi10.3389/fmed.2021.728866en
dcterms.bibliographicCitation.journaltitleFrontiers in Medicineen
dcterms.bibliographicCitation.originalpublishernameFrontiersen
dcterms.bibliographicCitation.originalpublisherplaceLausanneen
dcterms.bibliographicCitation.volume8en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften>Inst. Biotechnologie>FG Medizinische Biotechnologiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Medizinische Biotechnologiede
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
Files
Original bundle
Now showing 1 - 8 of 8
Loading…
Thumbnail Image
Name:
fmed-08-728866.pdf
Size:
3.18 MB
Format:
Adobe Portable Document Format
Description:
Loading…
Thumbnail Image
Name:
fmed-08-728866-g0001.tif
Size:
1.25 MB
Format:
Tag Image File Format
Description:
Loading…
Thumbnail Image
Name:
fmed-08-728866-g0002.tif
Size:
780.52 KB
Format:
Tag Image File Format
Description:
Loading…
Thumbnail Image
Name:
fmed-08-728866-g0003.tif
Size:
893.23 KB
Format:
Tag Image File Format
Description:
Loading…
Thumbnail Image
Name:
fmed-08-728866-g0004.tif
Size:
1.47 MB
Format:
Tag Image File Format
Description:
Loading…
Thumbnail Image
Name:
fmed-08-728866-g0005.tif
Size:
2.07 MB
Format:
Tag Image File Format
Description:
Loading…
Thumbnail Image
Name:
fmed-08-728866-g0006.tif
Size:
907.55 KB
Format:
Tag Image File Format
Description:
Loading…
Thumbnail Image
Name:
fmed-08-728866-g0007.tif
Size:
1.9 MB
Format:
Tag Image File Format
Description:
Collections