Chip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughput

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dc.contributor.authorMaterne, Eva-Maria
dc.contributor.authorTonevitsky, Alexander G.
dc.contributor.authorMarx, Uwe
dc.date.accessioned2016-06-24T05:35:14Z
dc.date.available2016-06-24T05:35:14Z
dc.date.issued2013
dc.descriptionDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.de
dc.descriptionThis publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.en
dc.description.abstractDrug-induced liver toxicity dominates the reasons for pharmaceutical product ban, withdrawal or non-approval since the thalidomide disaster in the late-1950s. Hopes to finally solve the liver toxicity test dilemma have recently risen to a historic level based on the latest progress in human microfluidic tissue culture devices. Chip-based human liver equivalents are envisaged to identify liver toxic agents regularly undiscovered by current test procedures at industrial throughput. In this review, we focus on advanced microfluidic microscale liver equivalents, appraising them against the level of architectural and, consequently, functional identity with their human counterpart in vivo. We emphasise the inherent relationship between human liver architecture and its drug-induced injury. Furthermore, we plot the current socio-economic drug development environment against the possible value such systems may add. Finally, we try to sketch a forecast for translational innovations in the field.en
dc.identifier.eissn1473-0197
dc.identifier.pmid23722971
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/5642
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-5262
dc.language.isoen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.ddc004 Datenverarbeitung; Informatikde
dc.subject.ddc570 Biowissenschaften; Biologiede
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.titleChip-based liver equivalents for toxicity testing - organotypicalness versus cost-efficient high throughputen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1039/c3lc50240f
dcterms.bibliographicCitation.issue18
dcterms.bibliographicCitation.journaltitleLab on a chip : miniaturisation for chemistry and biologyen
dcterms.bibliographicCitation.originalpublishernameRoyal Society of Chemistryde
dcterms.bibliographicCitation.originalpublisherplaceCambridgede
dcterms.bibliographicCitation.pageend3495
dcterms.bibliographicCitation.pagestart3481
dcterms.bibliographicCitation.volume13
tub.accessrights.dnbdomain
tub.affiliationFak. 3 Prozesswissenschaften::Inst. Biotechnologie::FG Medizinische Biotechnologiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Medizinische Biotechnologiede
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlin

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