Skin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusion

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dc.contributor.authorAtaƧ, Beren
dc.contributor.authorWagner, Ilka
dc.contributor.authorHorland, Reyk
dc.contributor.authorLauster, Roland
dc.contributor.authorMarx, Uwe
dc.contributor.authorTonevitsky, Alexander G.
dc.contributor.authorAzar, Reza P.
dc.contributor.authorLindner, Gerd
dc.date.accessioned2016-06-24T05:35:14Z
dc.date.available2016-06-24T05:35:14Z
dc.date.issued2013
dc.descriptionDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG gefƶrderten) Allianz- bzw. Nationallizenz frei zugƤnglich.de
dc.descriptionThis publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.en
dc.description.abstractSubstantial progress has been achieved over the last few decades in the development of skin equivalents to model the skin as an organ. However, their static culture still limits the emulation of essential physiological properties crucial for toxicity testing and compound screening. Here, we describe a dynamically perfused chip-based bioreactor platform capable of applying variable mechanical shear stress and extending culture periods. This leads to improvements of culture conditions for integrated in vitro skin models, ex vivo skin organ cultures and biopsies of single hair follicular units.en
dc.description.sponsorshipBMBF, 0315569, GO-Bio 3: Multi-Organ-Bioreaktoren fĆ¼r die prƤdiktive Substanztestung im Chipformaten
dc.description.sponsorshipDFG, GSC 203, Berlin-Brandenburg School for Regenerative Therapiesen
dc.identifier.eissn1473-0197
dc.identifier.pmid23674126
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/5644
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-5264
dc.language.isoen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.ddc004 Datenverarbeitung; Informatikde
dc.subject.ddc570 Biowissenschaften; Biologiede
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.titleSkin and hair on-a-chip: in vitro skin models versus ex vivo tissue maintenance with dynamic perfusionen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1039/c3lc50227a
dcterms.bibliographicCitation.issue18
dcterms.bibliographicCitation.journaltitleLab on a chip : miniaturisation for chemistry and biologyen
dcterms.bibliographicCitation.originalpublishernameRoyal Society of Chemistryde
dcterms.bibliographicCitation.originalpublisherplaceCambridgede
dcterms.bibliographicCitation.pageend3561
dcterms.bibliographicCitation.pagestart3555
dcterms.bibliographicCitation.volume13
tub.accessrights.dnbdomain
tub.affiliationFak. 3 Prozesswissenschaften::Inst. Biotechnologiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische UniversitƤt Berlin
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