Isomaltulose Enhances GLP‐1 and PYY Secretion to a Mixed Meal in People With or Without Type 2 Diabetes as Compared to Saccharose

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dc.contributor.authorZhang, Jiudan
dc.contributor.authorSonnenburg, Dominik
dc.contributor.authorTricò, Domenico
dc.contributor.authorKabisch, Stefan
dc.contributor.authorMari, Andrea
dc.contributor.authorTheis, Stephan
dc.contributor.authorKemper, Margrit
dc.contributor.authorPivovarova‐Ramich, Olga
dc.contributor.authorRohn, Sascha
dc.contributor.authorPfeiffer, Andreas F. H.
dc.date.accessioned2024-04-26T16:14:42Z
dc.date.available2024-04-26T16:14:42Z
dc.date.issued2024-02-08
dc.date.updated2024-04-15T22:36:48Z
dc.description.abstractScope: Secretion of the gut hormones glucagon-like peptide (GLP-1) and peptide YY (PYY) are induced by nutrients reaching the lower small intestine which regulate insulin and glucagon release, inhibit appetite, and may improve β-cell regeneration. The aim is to test the effect of a slowly digested isomaltulose (ISO) compared to the rapidly digested saccharose (SAC) as a snack given 1 h before a standardized mixed meal test (MMT) on GLP-1, PYY, glucose-dependent insulinotropic peptide (GIP), and metabolic responses in participants with or without type 2 diabetes (T2DM). Methods and results: Fifteen healthy volunteers and 15 patients with T2DM consumed either 50 g ISO or SAC 1 h preload of MMT on nonconsecutive days. Clinical parameters and incretin hormones are measured throughout the whole course of MMT. Administration of 50 g ISO as compared to SAC induced a significant increase in GLP-1, GIP, and PYY responses over 2 h after intake of a typical lunch in healthy controls. Patients with T2DM showed reduced overall responses of GLP-1 and delayed insulin release compared to controls while ISO significantly enhanced the GIP and almost tripled the PYY response compared to SAC. Conclusion: A snack containing ISO markedly enhances the release of the metabolically advantageous gut hormones PYY and GLP-1 and enhances GIP release in response to a subsequent complex meal.en
dc.identifier.eissn1613-4133
dc.identifier.issn1613-4125
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/21540
dc.identifier.urihttps://doi.org/10.14279/depositonce-20340
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.subject.ddc600 Technik, Medizin, angewandte Wissenschaften::660 Chemische Verfahrenstechnik::664 Lebensmitteltechnologie
dc.subject.otherincretin hormones
dc.subject.otherisomaltulose
dc.subject.otherpostprandial metabolism
dc.subject.othersaccharose
dc.subject.otherT2DM
dc.titleIsomaltulose Enhances GLP‐1 and PYY Secretion to a Mixed Meal in People With or Without Type 2 Diabetes as Compared to Saccharoseen
dc.typeArticle
dc.type.versionpublishedVersion
dcterms.bibliographicCitation.articlenumber2300086
dcterms.bibliographicCitation.doi10.1002/mnfr.202300086
dcterms.bibliographicCitation.issue4
dcterms.bibliographicCitation.journaltitleMolecular Nutrition & Food Researchen
dcterms.bibliographicCitation.originalpublishernameWiley-VCH
dcterms.bibliographicCitation.originalpublisherplaceWeinheim
dcterms.bibliographicCitation.pageend
dcterms.bibliographicCitation.pagestart
dcterms.bibliographicCitation.volume68
dcterms.rightsHolder.referenceCreative-Commons-Lizenz
tub.accessrights.dnbfree
tub.affiliationFak. 3 Prozesswissenschaften::Inst. Lebensmitteltechnologie und Lebensmittelchemie::FG Lebensmittelchemie und Analytik
tub.publisher.universityorinstitutionTechnische Universität Berlin

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