dc.contributor.author	Priesemann, Viola
dc.contributor.author	Wibral, Michael
dc.contributor.author	Valderrama, Mario
dc.contributor.author	Pröpper, Robert
dc.contributor.author	Le Van Quyen, Michel
dc.contributor.author	Geisel, Theo
dc.contributor.author	Triesch, Jochen
dc.contributor.author	Nikolić, Danko
dc.contributor.author	Munk, Matthias H. J.
dc.date.accessioned	2019-11-18T14:03:11Z
dc.date.available	2019-11-18T14:03:11Z
dc.date.issued	2014-06-24
dc.date.updated	2019-10-04T00:20:59Z
dc.description.abstract	In self-organized critical (SOC) systems avalanche size distributions follow power-laws. Power-laws have also been observed for neural activity, and so it has been proposed that SOC underlies brain organization as well. Surprisingly, for spiking activity in vivo, evidence for SOC is still lacking. Therefore, we analyzed highly parallel spike recordings from awake rats and monkeys, anesthetized cats, and also local field potentials from humans. We compared these to spiking activity from two established critical models: the Bak-Tang-Wiesenfeld model, and a stochastic branching model. We found fundamental differences between the neural and the model activity. These differences could be overcome for both models through a combination of three modifications: (1) subsampling, (2) increasing the input to the model (this way eliminating the separation of time scales, which is fundamental to SOC and its avalanche definition), and (3) making the model slightly sub-critical. The match between the neural activity and the modified models held not only for the classical avalanche size distributions and estimated branching parameters, but also for two novel measures (mean avalanche size, and frequency of single spikes), and for the dependence of all these measures on the temporal bin size. Our results suggest that neural activity in vivo shows a mélange of avalanches, and not temporally separated ones, and that their global activity propagation can be approximated by the principle that one spike on average triggers a little less than one spike in the next step. This implies that neural activity does not reflect a SOC state but a slightly sub-critical regime without a separation of time scales. Potential advantages of this regime may be faster information processing, and a safety margin from super-criticality, which has been linked to epilepsy.	en
dc.description.sponsorship	DFG, 103586207, GRK 1589: Verarbeitung sensorischer Informationen in neuronalen Systemen	en
dc.description.sponsorship	BMBF, 01GQ1005B, Bernstein Zentrum für Computational Neuroscience, Göttingen - Kooperative Dynamiken und Adaptivität in neuronalen Systemen	en
dc.description.sponsorship	BMBF, 01GQ0742, Verbundprojekt Bernstein Partner: Gedächtnis-Netzwerk, Teilprojekt 2	en
dc.identifier.eissn	1662-5137
dc.identifier.uri	https://depositonce.tu-berlin.de/handle/11303/10324
dc.identifier.uri	http://dx.doi.org/10.14279/depositonce-9286
dc.language.iso	en	en
dc.rights.uri	https://creativecommons.org/licenses/by/3.0/	en
dc.subject.ddc	612 Humanphysiologie	de
dc.subject.other	self-organized criticality	en
dc.subject.other	human intracranial recordings	en
dc.subject.other	spike train analysis	en
dc.subject.other	highly parallel recordings	en
dc.subject.other	spiking neural networks	en
dc.subject.other	multiunit activity	en
dc.subject.other	cortex	en
dc.subject.other	monkeys	en
dc.title	Spike avalanches in vivo suggest a driven, slightly subcritical brain state	en
dc.type	Article	en
dc.type.version	publishedVersion	en
dcterms.bibliographicCitation.articlenumber	108	en
dcterms.bibliographicCitation.doi	10.3389/fnsys.2014.00108	en
dcterms.bibliographicCitation.journaltitle	Frontiers in Systems Neuroscience	en
dcterms.bibliographicCitation.originalpublishername	Frontiers Media S.A.	en
dcterms.bibliographicCitation.originalpublisherplace	Lausanne	en
dcterms.bibliographicCitation.volume	8	en
tub.accessrights.dnb	free	en
tub.affiliation	Fak. 4 Elektrotechnik und Informatik::Inst. Softwaretechnik und Theoretische Informatik::FG Neuronale Informationsverarbeitung	de
tub.affiliation.faculty	Fak. 4 Elektrotechnik und Informatik	de
tub.affiliation.group	FG Neuronale Informationsverarbeitung	de
tub.affiliation.institute	Inst. Softwaretechnik und Theoretische Informatik	de
tub.publisher.universityorinstitution	Technische Universität Berlin	en

Spike avalanches in vivo suggest a driven, slightly subcritical brain state

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