In vivo detection of changes in cutaneous carotenoids after chemotherapy using shifted excitation resonance Raman difference and fluorescence spectroscopy

dc.contributor.authorJung, Sora
dc.contributor.authorDarvin, Maxim E.
dc.contributor.authorSchleusener, Johannes
dc.contributor.authorThiede, Gisela
dc.contributor.authorLademann, Juergen
dc.contributor.authorBraune, Marcel
dc.contributor.authorMaiwald, Martin
dc.contributor.authorSumpf, Bernd
dc.contributor.authorTränkle, Günther
dc.contributor.authorKutzer, Dunja
dc.contributor.authorElban, Felia
dc.contributor.authorFuss, Harald
dc.date.accessioned2020-11-16T11:43:46Z
dc.date.available2020-11-16T11:43:46Z
dc.date.issued2020-01-06
dc.date.updated2020-10-19T20:34:48Z
dc.description.abstractBackground: Various cutaneous toxicities under chemotherapy indicate a local effect of chemotherapy by secretion after systemic application. Here, changes in the fluorescence and Raman spectral properties of the stratum corneum subsequent to intravenous chemotherapy were assessed. Methods: Twenty healthy subjects and 20 cancer patients undergoing chemotherapy were included. Measurement time points in cancer patients were before the first cycle of chemotherapy (Tbase) and immediately after intravenous application of the chemotherapy (T1). Healthy subjects were measured once without any further intervention. Measurements were conducted using an individually manufactured system consisting of a handheld probe and a wavelength‐tunable diode laser‐based 488 nm SHG light source. Hereby, changes in both skin fluorescence and shifted excitation resonance Raman difference spectroscopy (SERRDS) carotenoid signals were assessed. Results: Healthy subjects showed significantly (P < .001) higher mean concentrations of carotenoids compared to cancer subjects at Tbase. An increase in fluorescence intensity was detected in almost all patients after chemotherapy, especially after doxorubicin infusion. Furthermore, a decrease in the carotenoid concentration in the skin after chemotherapy was found. Conclusion: The SERRDS based noninvasive detection can be used as an indirect quantitative assessment of fluorescent chemotherapeutics. The lower carotenoid SERRDS intensities at Tbase might be due to cancerous diseases and co‐medication.en
dc.identifier.eissn1600-0846
dc.identifier.issn0909-752X
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/11961
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-10843
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc610 Medizin und Gesundheitde
dc.subject.othercarotenoidsen
dc.subject.otherchemotherapyen
dc.subject.otherfluorescenceen
dc.subject.otherRaman difference spectroscopyen
dc.subject.othershifted excitation resonanceen
dc.titleIn vivo detection of changes in cutaneous carotenoids after chemotherapy using shifted excitation resonance Raman difference and fluorescence spectroscopyen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1111/srt.12800en
dcterms.bibliographicCitation.issue2en
dcterms.bibliographicCitation.journaltitleSkin Research and Technologyen
dcterms.bibliographicCitation.originalpublishernameWileyen
dcterms.bibliographicCitation.originalpublisherplaceNew York, NYen
dcterms.bibliographicCitation.pageend307en
dcterms.bibliographicCitation.pagestart301en
dcterms.bibliographicCitation.volume26en
tub.accessrights.dnbfreeen
tub.affiliationFak. 4 Elektrotechnik und Informatik::Inst. Hochfrequenz- und Halbleiter-Systemtechnologien::FG Mikrowellen- und Optoelektronikde
tub.affiliation.facultyFak. 4 Elektrotechnik und Informatikde
tub.affiliation.groupFG Mikrowellen- und Optoelektronikde
tub.affiliation.instituteInst. Hochfrequenz- und Halbleiter-Systemtechnologiende
tub.publisher.universityorinstitutionTechnische Universität Berlinen

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