Microwave-Assisted Synthesis of 5′-O-methacryloylcytidine Using the Immobilized Lipase Novozym 435

dc.contributor.authorChea, Sany
dc.contributor.authorNguyen, Khac Toan
dc.contributor.authorRosencrantz, Ruben R.
dc.date.accessioned2022-07-11T12:27:23Z
dc.date.available2022-07-11T12:27:23Z
dc.date.issued2022-06-26
dc.date.updated2022-07-08T11:14:13Z
dc.description.abstractNucleobase building blocks have been demonstrated to be strong candidates when it comes to DNA/RNA-like materials by benefiting from hydrogen bond interactions as physical properties. Modifying at the 5′ position is the simplest way to develop nucleobase-based structures by transesterification using the lipase Novozym 435. Herein, we describe the optimization of the lipase-catalyzed synthesis of the monomer 5′-O-methacryloylcytidine with the assistance of microwave irradiation. Variable reaction parameters, such as enzyme concentration, molar ratio of the substrate, reaction temperature and reaction time, were investigated to find the optimum reaction condition in terms of obtaining the highest yield.en
dc.identifier.eissn1420-3049
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/17218
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-15997
dc.language.isoenen
dc.rightsLicensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.subject.othermicrowave irradiationen
dc.subject.otherNovozym 435en
dc.subject.othercytidineen
dc.subject.othermonomeren
dc.subject.othersmart materialsen
dc.titleMicrowave-Assisted Synthesis of 5′-O-methacryloylcytidine Using the Immobilized Lipase Novozym 435en
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber4112en
dcterms.bibliographicCitation.doi10.3390/molecules27134112en
dcterms.bibliographicCitation.issue13en
dcterms.bibliographicCitation.journaltitleMoleculesen
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume27en
tub.accessrights.dnbfreeen
tub.affiliationFak. 2 Mathematik und Naturwissenschaften>Inst. Chemiede
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
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