Something old, something new: challenges and developments in Aspergillus niger biotechnology
| dc.contributor.author | Cairns, Timothy C. | |
| dc.contributor.author | Barthel, Lars | |
| dc.contributor.author | Meyer, Vera | |
| dc.date.accessioned | 2021-11-04T09:41:38Z | |
| dc.date.available | 2021-11-04T09:41:38Z | |
| dc.date.issued | 2021-07-26 | |
| dc.description.abstract | The filamentous ascomycete fungus Aspergillus niger is a prolific secretor of organic acids, proteins, enzymes and secondary metabolites. Throughout the last century, biotechnologists have developed A. niger into a multipurpose cell factory with a product portfolio worth billions of dollars each year. Recent technological advances, from genome editing to other molecular and omics tools, promise to revolutionize our understanding of A. niger biology, ultimately to increase efficiency of existing industrial applications or even to make entirely new products. However, various challenges to this biotechnological vision, many several decades old, still limit applications of this fungus. These include an inability to tightly control A. niger growth for optimal productivity, and a lack of high-throughput cultivation conditions for mutant screening. In this mini-review, we summarize the current state-of-the-art for A. niger biotechnology with special focus on organic acids (citric acid, malic acid, gluconic acid and itaconic acid), secreted proteins and secondary metabolites, and discuss how new technological developments can be applied to comprehensively address a variety of old and persistent challenges. | en |
| dc.description.sponsorship | DFG, 273937032, SPP 1934: Dispersitäts-, Struktur- und Phasenänderungen von Proteinen und biologischen Agglomeraten in biotechnologischen Prozessen | en |
| dc.identifier.eissn | 1744-1358 | |
| dc.identifier.issn | 0071-1365 | |
| dc.identifier.uri | https://depositonce.tu-berlin.de/handle/11303/13804 | |
| dc.identifier.uri | http://dx.doi.org/10.14279/depositonce-12580 | |
| dc.language.iso | en | en |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject.ddc | 540 Chemie und zugeordnete Wissenschaften | de |
| dc.subject.other | Aspergillus niger | en |
| dc.subject.other | citric acid | en |
| dc.subject.other | glucoamylase | en |
| dc.subject.other | macromorphology | en |
| dc.subject.other | micro-computer tomography | en |
| dc.subject.other | secondary metabolite | en |
| dc.title | Something old, something new: challenges and developments in Aspergillus niger biotechnology | en |
| dc.type | Article | en |
| dc.type.version | publishedVersion | en |
| dcterms.bibliographicCitation.doi | 10.1042/EBC20200139 | en |
| dcterms.bibliographicCitation.issue | 2 | en |
| dcterms.bibliographicCitation.journaltitle | Essays in Biochemistry | en |
| dcterms.bibliographicCitation.originalpublishername | Portland Press | en |
| dcterms.bibliographicCitation.originalpublisherplace | London | en |
| dcterms.bibliographicCitation.pageend | 224 | en |
| dcterms.bibliographicCitation.pagestart | 213 | en |
| dcterms.bibliographicCitation.volume | 65 | en |
| tub.accessrights.dnb | free | en |
| tub.affiliation | Fak. 3 Prozesswissenschaften::Inst. Biotechnologie::FG Angewandte und Molekulare Mikrobiologie | de |
| tub.affiliation.faculty | Fak. 3 Prozesswissenschaften | de |
| tub.affiliation.group | FG Angewandte und Molekulare Mikrobiologie | de |
| tub.affiliation.institute | Inst. Biotechnologie | de |
| tub.publisher.universityorinstitution | Technische Universität Berlin | en |