Something old, something new: challenges and developments in Aspergillus niger biotechnology

dc.contributor.authorCairns, Timothy C.
dc.contributor.authorBarthel, Lars
dc.contributor.authorMeyer, Vera
dc.date.accessioned2021-11-04T09:41:38Z
dc.date.available2021-11-04T09:41:38Z
dc.date.issued2021-07-26
dc.description.abstractThe filamentous ascomycete fungus Aspergillus niger is a prolific secretor of organic acids, proteins, enzymes and secondary metabolites. Throughout the last century, biotechnologists have developed A. niger into a multipurpose cell factory with a product portfolio worth billions of dollars each year. Recent technological advances, from genome editing to other molecular and omics tools, promise to revolutionize our understanding of A. niger biology, ultimately to increase efficiency of existing industrial applications or even to make entirely new products. However, various challenges to this biotechnological vision, many several decades old, still limit applications of this fungus. These include an inability to tightly control A. niger growth for optimal productivity, and a lack of high-throughput cultivation conditions for mutant screening. In this mini-review, we summarize the current state-of-the-art for A. niger biotechnology with special focus on organic acids (citric acid, malic acid, gluconic acid and itaconic acid), secreted proteins and secondary metabolites, and discuss how new technological developments can be applied to comprehensively address a variety of old and persistent challenges.en
dc.description.sponsorshipDFG, 273937032, SPP 1934: Dispersitäts-, Struktur- und Phasenänderungen von Proteinen und biologischen Agglomeraten in biotechnologischen Prozessenen
dc.identifier.eissn1744-1358
dc.identifier.issn0071-1365
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/13804
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-12580
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.subject.otherAspergillus nigeren
dc.subject.othercitric aciden
dc.subject.otherglucoamylaseen
dc.subject.othermacromorphologyen
dc.subject.othermicro-computer tomographyen
dc.subject.othersecondary metaboliteen
dc.titleSomething old, something new: challenges and developments in Aspergillus niger biotechnologyen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1042/EBC20200139en
dcterms.bibliographicCitation.issue2en
dcterms.bibliographicCitation.journaltitleEssays in Biochemistryen
dcterms.bibliographicCitation.originalpublishernamePortland Pressen
dcterms.bibliographicCitation.originalpublisherplaceLondonen
dcterms.bibliographicCitation.pageend224en
dcterms.bibliographicCitation.pagestart213en
dcterms.bibliographicCitation.volume65en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften>Inst. Biotechnologie>FG Angewandte und Molekulare Mikrobiologiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Angewandte und Molekulare Mikrobiologiede
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
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