From axenic to mixed cultures: technological advances accelerating a paradigm shift in microbiology

dc.contributor.authorMeyer, Vera
dc.contributor.authorNai, Corrado
dc.date.accessioned2017-12-06T08:54:04Z
dc.date.available2017-12-06T08:54:04Z
dc.date.issued2017
dc.description.abstractSince the onset of microbiology in the late 19th century, scientists have been growing microorganisms almost exclusively as pure cultures, resulting in a limited and biased view of the microbial world. Only a paradigm shift in cultivation techniques – from axenic to mixed cultures – can allow a full comprehension of the (chemical) communication of microorganisms, with profound consequences for natural product discovery, microbial ecology, symbiosis, and pathogenesis, to name a few areas. Three main technical advances during the last decade are fueling the realization of this revolution in microbiology: microfluidics, next-generation 3D-bioprinting, and single-cell metabolomics. These technological advances can be implemented for large-scale, systematic cocultivation studies involving three or more microorganisms. In this review, we present recent trends in microbiology tools and discuss how these can be employed to decode the chemical language that microorganisms use to communicate.en
dc.identifier.issn1878-4380
dc.identifier.urihttps://depositonce.tu-berlin.de//handle/11303/7248
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-6524
dc.language.isoenen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subject.ddc570 Biowissenschaften; Biologiede
dc.subject.othercocultivation (co-cultivation) devicesen
dc.subject.othercoculture (co-culture)en
dc.subject.othermicrofluidic devicesen
dc.subject.othernatural product discoveryen
dc.subject.othermicrobial secondary metabolismen
dc.subject.othermicrobial communicationen
dc.titleFrom axenic to mixed cultures: technological advances accelerating a paradigm shift in microbiologyen
dc.typeArticleen
dc.type.versionacceptedVersionen
dcterms.bibliographicCitation.articlenumberTIMI 1521en
dcterms.bibliographicCitation.doi10.1016/j.tim.2017.11.004en
dcterms.bibliographicCitation.journaltitleTrends in Microbiologyen
dcterms.bibliographicCitation.originalpublishernameElsevieren
dcterms.bibliographicCitation.originalpublisherplaceAmsterdam [u.a.]en
dcterms.bibliographicCitation.pageend18en
dcterms.bibliographicCitation.pagestart1en
tub.accessrights.dnbdomain*
tub.affiliationFak. 3 Prozesswissenschaften>Inst. Biotechnologie>FG Angewandte und Molekulare Mikrobiologiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Angewandte und Molekulare Mikrobiologiede
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
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