Pyrrolysyl-tRNA-Synthetase: Methanogenese und Gencode-Erweiterung
dc.contributor.author | Koch, Nikolaj Georg | |
dc.contributor.author | Budisa, Nediljko | |
dc.date.accessioned | 2021-12-13T07:04:20Z | |
dc.date.available | 2021-12-13T07:04:20Z | |
dc.date.issued | 2021-10-09 | |
dc.description.abstract | Pyrrolysyl-tRNA synthetase (PylRS) is an enzyme of some methanogenic Archaea for the natural incorporation of pyrrolysine into proteins. The discovery of PylRS as a natural tool for genetic code expansion paved the way for site-specific incorporation of non-canonical amino acids (ncAAs) into proteins, with versatile side chains useful in biotechnology. Almost 20 years after the discovery, we describe the journey which led to three distinct classes of PylRSs with unique ncAA recognitions. | en |
dc.description.sponsorship | TU Berlin, Open-Access-Mittel – 2021 | en |
dc.identifier.eissn | 1868-6249 | |
dc.identifier.issn | 0947-0867 | |
dc.identifier.uri | https://depositonce.tu-berlin.de/handle/11303/14031 | |
dc.identifier.uri | http://dx.doi.org/10.14279/depositonce-12804 | |
dc.language.iso | de | en |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en |
dc.subject.ddc | 570 Biowissenschaften; Biologie | de |
dc.subject.ddc | 540 Chemie und zugeordnete Wissenschaften | de |
dc.subject.other | PylRS | en |
dc.subject.other | synthetase | en |
dc.subject.other | genetic code | en |
dc.subject.other | enzyme | en |
dc.subject.other | protein | en |
dc.title | Pyrrolysyl-tRNA-Synthetase: Methanogenese und Gencode-Erweiterung | de |
dc.type | Article | en |
dc.type.version | publishedVersion | en |
dcterms.bibliographicCitation.doi | 10.1007/s12268-021-1653-x | en |
dcterms.bibliographicCitation.issue | 6 | en |
dcterms.bibliographicCitation.journaltitle | BIOspektrum | en |
dcterms.bibliographicCitation.originalpublishername | Springer Nature | en |
dcterms.bibliographicCitation.originalpublisherplace | Heidelberg | en |
dcterms.bibliographicCitation.pageend | 619 | en |
dcterms.bibliographicCitation.pagestart | 616 | en |
dcterms.bibliographicCitation.volume | 27 | en |
tub.accessrights.dnb | free | en |
tub.affiliation | Fak. 2 Mathematik und Naturwissenschaften::Inst. Chemie::FG Biokatalyse | de |
tub.affiliation.faculty | Fak. 2 Mathematik und Naturwissenschaften | |
tub.affiliation.group | FG Biokatalyse | |
tub.affiliation.institute | Inst. Chemie | |
tub.publisher.universityorinstitution | Technische Universität Berlin | en |
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