Is Spreading Depolarization Characterized by an Abrupt, Massive Release of Gibbs Free Energy from the Human Brain Cortex?

dc.contributor.authorDreier, Jens P.
dc.contributor.authorIsele, Thomas
dc.contributor.authorReiffurth, Clemens
dc.contributor.authorOffenhauser, Nikolas
dc.contributor.authorKirov, Sergei A.
dc.contributor.authorDahlem, Markus A.
dc.contributor.authorHerreras, Oscar
dc.date.accessioned2019-01-08T17:31:59Z
dc.date.available2019-01-08T17:31:59Z
dc.date.issued2013
dc.descriptionDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.de
dc.descriptionThis publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.en
dc.description.abstractIn the evolution of the cerebral cortex, the sophisticated organization in a steady state far away from thermodynamic equilibrium has produced the side effect of two fundamental pathological network events: ictal epileptic activity and spreading depolarization. Ictal epileptic activity describes the partial disruption, and spreading depolarization describes the near-complete disruption of the physiological double Gibbs–Donnan steady state. The occurrence of ictal epileptic activity in patients has been known for decades. Recently, unequivocal electrophysiological evidence has been found in patients that spreading depolarizations occur abundantly in stroke and brain trauma. The authors propose that the ion changes can be taken to estimate relative changes in Gibbs free energy from state to state. The calculations suggest that in transitions from the physiological state to ictal epileptic activity to spreading depolarization to death, the cortex releases Gibbs free energy in a stepwise fashion. Spreading depolarization thus appears as a twilight state close to death. Consistently, electrocorticographic recordings in the core of focal ischemia or after cardiac arrest display a smooth transition from the initial spreading depolarization component to the later ultraslow negative potential, which is assumed to reflect processes in cellular death.en
dc.description.sponsorshipBMBF, 01EO0801, Centrum für Schlaganfallforschung Berlin (CSB)en
dc.description.sponsorshipBMBF, 01GQ1001C, Verbundprojekt: Bernstein Zentrum für Computational Neuroscience, Berlin - "Präzision und Variabilität" - Teilprojekt A1, A3, A5, A6, B1, B2, B4 und B6en
dc.identifier.eissn1089-4098
dc.identifier.issn1073-8584
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/8844
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-7973
dc.language.isoen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subject.ddc150 Psychologiede
dc.subject.otherspreading depressionen
dc.subject.otherstrokeen
dc.subject.othersubarachnoid hemorrhageen
dc.subject.otherintracerebral hemorrhageen
dc.subject.othertraumatic brain injuryen
dc.subject.otherepilepsyen
dc.subject.othermigraineen
dc.titleIs Spreading Depolarization Characterized by an Abrupt, Massive Release of Gibbs Free Energy from the Human Brain Cortex?en
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1177/1073858412453340
dcterms.bibliographicCitation.issue1
dcterms.bibliographicCitation.journaltitleThe Neuroscientisten
dcterms.bibliographicCitation.originalpublishernameSAGE Publicationsen
dcterms.bibliographicCitation.originalpublisherplaceWashington, DCen
dcterms.bibliographicCitation.pageend42
dcterms.bibliographicCitation.pagestart25
dcterms.bibliographicCitation.volume19
tub.accessrights.dnbdomain
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Theoretische Physikde
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.instituteInst. Theoretische Physikde
tub.publisher.universityorinstitutionTechnische Universität Berlinde

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