NAD(H)-coupled hydrogen cycling - structure-function relationships of bidirectional [NiFe] hydrogenases

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dc.contributor.authorHorch, Marius
dc.contributor.authorLauterbach, Lars
dc.contributor.authorLenz, Oliver
dc.contributor.authorHildebrandt, Peter
dc.contributor.authorZebger, Ingo
dc.date.accessioned2017-07-14T10:50:13Z
dc.date.available2017-07-14T10:50:13Z
dc.date.issued2012
dc.description.abstractHydrogenases catalyze the activation or production of molecular hydrogen. Due to their potential importance for future biotechnological applications, these enzymes have been in the focus of intense research for the past decades. Bidirectional [NiFe] hydrogenases are of particular interest as they couple the reversible cleavage of hydrogen to the redox conversion of NAD(H). In this account, we review the current state of knowledge about mechanistic aspects and structural determinants of these complex multi-cofactor enzymes. Special emphasis is laid on the oxygen-tolerant NAD(H)-linked bidirectional [NiFe] hydrogenase from Ralstonia eutropha. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.en
dc.identifier.eissn1873-3468
dc.identifier.issn0014-5793
dc.identifier.pmid22056977
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/6501
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-6009
dc.language.isoen
dc.relation.ispartof10.14279/depositonce-4518
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc570 Biowissenschaften; Biologiede
dc.subject.ddc530 Physikde
dc.subject.ddc610 Medizin und Gesundheitde
dc.subject.otherBiocatalysisen
dc.subject.otherHydrogenaseen
dc.subject.otherSpectroscopyen
dc.subject.otherOxygen toleranceen
dc.subject.otherNADH regenerationen
dc.subject.otherBiofuelen
dc.titleNAD(H)-coupled hydrogen cycling - structure-function relationships of bidirectional [NiFe] hydrogenasesen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1016/j.febslet.2011.10.010
dcterms.bibliographicCitation.issue5
dcterms.bibliographicCitation.journaltitleFEBS lettersen
dcterms.bibliographicCitation.originalpublishernameElsevieren
dcterms.bibliographicCitation.originalpublisherplaceAmsterdam [u.a.]en
dcterms.bibliographicCitation.pageend556
dcterms.bibliographicCitation.pagestart545
dcterms.bibliographicCitation.volume586
tub.accessrights.dnbfree
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Chemie::FG Physikalische Chemie / Biophysikalische Chemiede
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.groupFG Physikalische Chemie / Biophysikalische Chemiede
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlin

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