Rheological characteristics of filamentous cultivation broths and suitable model fluids

dc.contributor.authorBliatsiou, Chrysoula
dc.contributor.authorSchrinner, Kathrin
dc.contributor.authorWaldherr, Chrysoula
dc.contributor.authorTesche, Sebastian
dc.contributor.authorBöhm, Lutz
dc.contributor.authorKraume, Matthias
dc.contributor.authorKrull, Rainer
dc.date.accessioned2022-08-03T08:20:16Z
dc.date.available2022-08-03T08:20:16Z
dc.date.issued2020-08-03
dc.description.abstractThe rheological characteristics of cultivations with filamentous microorganisms define many other crucial process parameters in the system, such as the cell morphology and the productivity. The present study aims to determine the rheological changes of broths during batch cultivations of three filamentous microorganisms: the fungus Aspergillus niger, and the two actinomycetes Lentzea aerocolonigenes and Actinomadura namibiensis. Focus is given on establishing measurement methodologies to characterize these heterogeneous filamentous systems. For the rheological characterisation the Ostwald-de Waele power law approach is used. All examined biological filamentous broths exhibit a non-Newtonian shear thinning behavior. The effect of biomass concentration and cell morphology on the rheology of the broth is further enlightened. Finally, the rheology of the cultivation broths is compared with that of various model fluids to test the suitability of the last ones to mimic rheologically the biological broths in further technical applications.en
dc.description.sponsorshipDFG, 273937032, SPP 1934: Dispersitäts-, Struktur- und Phasenänderungen von Proteinen und biologischen Agglomeraten in biotechnologischen Prozessenen
dc.identifier.eissn1873-295X
dc.identifier.issn1369-703X
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/17293
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-16074
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc660 Chemische Verfahrenstechnikde
dc.subject.otherrheologyen
dc.subject.otherfilamentous cultivation brothen
dc.subject.othercell morphologyen
dc.subject.othermodel fluid systemen
dc.subject.othernon-newtonian behavioren
dc.titleRheological characteristics of filamentous cultivation broths and suitable model fluidsen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber107746en
dcterms.bibliographicCitation.doi10.1016/j.bej.2020.107746en
dcterms.bibliographicCitation.journaltitleBiochemical Engineering Journalen
dcterms.bibliographicCitation.originalpublishernameElsevieren
dcterms.bibliographicCitation.originalpublisherplaceAmsterdamen
dcterms.bibliographicCitation.volume163en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften>Inst. Prozess- und Verfahrenstechnik>FG Verfahrenstechnikde
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Verfahrenstechnikde
tub.affiliation.instituteInst. Prozess- und Verfahrenstechnikde
tub.publisher.universityorinstitutionTechnische Universität Berlinen
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