Pervasive coexpression of spatially proximal genes is buffered at the protein level

dc.contributor.authorKustatscher, Georg
dc.contributor.authorGrabowski, Piotr
dc.contributor.authorRappsilber, Juri
dc.date.accessioned2020-11-18T08:04:50Z
dc.date.available2020-11-18T08:04:50Z
dc.date.issued2017-08-23
dc.description.abstractGenes are not randomly distributed in the genome. In humans, 10% of protein‐coding genes are transcribed from bidirectional promoters and many more are organised in larger clusters. Intriguingly, neighbouring genes are frequently coexpressed but rarely functionally related. Here we show that coexpression of bidirectional gene pairs, and closeby genes in general, is buffered at the protein level. Taking into account the 3D architecture of the genome, we find that co‐regulation of spatially close, functionally unrelated genes is pervasive at the transcriptome level, but does not extend to the proteome. We present evidence that non‐functional mRNA coexpression in human cells arises from stochastic chromatin fluctuations and direct regulatory interference between spatially close genes. Protein‐level buffering likely reflects a lack of coordination of post‐transcriptional regulation of functionally unrelated genes. Grouping human genes together along the genome sequence, or through long‐range chromosome folding, is associated with reduced expression noise. Our results support the hypothesis that the selection for noise reduction is a major driver of the evolution of genome organisation.en
dc.identifier.eissn1744-4292
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/11986
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-10866
dc.language.isoenen
dc.relation.ispartof10.14279/depositonce-9070
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc570 Biowissenschaften; Biologiede
dc.subject.othergene expression noiseen
dc.subject.othergenome organisationen
dc.subject.otherproteomicsen
dc.subject.otherregulatory interferenceen
dc.subject.othertranscriptomicsen
dc.titlePervasive coexpression of spatially proximal genes is buffered at the protein levelen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber937en
dcterms.bibliographicCitation.doi10.15252/msb.20177548en
dcterms.bibliographicCitation.issue8en
dcterms.bibliographicCitation.journaltitleMolecular Systems Biologyen
dcterms.bibliographicCitation.originalpublishernameEMBO Pressen
dcterms.bibliographicCitation.originalpublisherplaceHeidelbergen
dcterms.bibliographicCitation.volume13en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften::Inst. Biotechnologie::FG Bioanalytikde
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Bioanalytikde
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen

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