Enhancing the stability of spontaneously self-assembled vesicles - the effect of polymer architecture

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dc.contributor.authorBressel, Katharina
dc.contributor.authorGradzielski, Michael
dc.date.accessioned2017-10-25T06:27:57Z
dc.date.available2017-10-25T06:27:57Z
dc.date.issued2015
dc.description.abstractThe formation of stable vesicles with a controlled size and high stability is an important matter due to their wide application in pharmaceutical and detergency formulations and as drug delivery vehicles. One can control the size of spontaneously formed vesicles in mixtures of zwitterionic and anionic surfactants by the admixture of small amounts of an amphiphilic copolymer of the PEO-PPO-PEO type. Of course, this effect should depend largely on the molecular architecture of the copolymer employed which was varied systematically in this work, and the temporal evolution of aggregate size and final structure was followed by means of DLS and three main effects could be observed. First the size of the formed vesicles is the larger the higher the molecular weight (MW) of the polymer and the higher the polymer concentration. Secondly the amount of copolymer required to induce long time stability is inversely proportional to the fraction of PEO in the polymer. Finally the architecture for a given MW and PEO/PPO ratio has no effect on the vesicle structure but their structure is directly controlled by the length of the PPO block of the copolymer. Thereby by appropriate choice of type and amount of PEO-PPO-PEO copolymer one can exert comprehensive control over size and stability of unilamellar vesicles.en
dc.description.sponsorshipDFG, SPP 1273, Kolloidverfahrenstechniken
dc.identifier.eissn1744-6848
dc.identifier.issn1744-683X
dc.identifier.pmid25668397
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/6970
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-6309
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subject.ddc530 Physikde
dc.titleEnhancing the stability of spontaneously self-assembled vesicles - the effect of polymer architectureen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1039/c4sm02746a
dcterms.bibliographicCitation.issue12
dcterms.bibliographicCitation.journaltitleSoft matteren
dcterms.bibliographicCitation.originalpublishernameRoyal Society of Chemistryde
dcterms.bibliographicCitation.originalpublisherplaceCambridgede
dcterms.bibliographicCitation.pageend2453
dcterms.bibliographicCitation.pagestart2445
dcterms.bibliographicCitation.volume11
tub.accessrights.dnbfree
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Chemie::FG Physikalische Chemie / Molekulare Materialwissenschaftende
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.groupFG Physikalische Chemie / Molekulare Materialwissenschaftende
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlin

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