The Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Study

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dc.contributor.authorHeilos, Daniela
dc.contributor.authorRodríguez-Carrasco, Yelko
dc.contributor.authorEnglinger, Bernhard
dc.contributor.authorTimelthaler, Gerald
dc.contributor.authorVan Schoonhoven, Sushilla
dc.contributor.authorSulyok, Michael
dc.contributor.authorBoecker, Simon
dc.contributor.authorSüßmuth, Roderich D.
dc.contributor.authorHeffeter, Petra
dc.contributor.authorLemmens-Gruber, Rosa
dc.contributor.authorDornetshuber-Fleiss, Rita
dc.contributor.authorBerger, Walter
dc.date.accessioned2019-09-16T14:48:00Z
dc.date.available2019-09-16T14:48:00Z
dc.date.issued2017-08-24
dc.date.updated2019-07-31T17:25:59Z
dc.description.abstractRecently, in vitro anti-cancer properties of beauvericin, a fungal metabolite were shown in various cancer cell lines. In this study, we assessed the specificity of this effect by comparing beauvericin cytotoxicity in malignant versus non-malignant cells. Moreover, we tested in vivo anticancer effects of beauvericin by treating BALB/c and CB-17/SCID mice bearing murine CT-26 or human KB-3-1-grafted tumors, respectively. Tumor size and weight were measured and histological sections were evaluated by Ki-67 and H/E staining as well as TdT-mediated-dUTP-nick-end (TUNEL) labeling. Beauvericin levels were determined in various tissues and body fluids by LC-MS/MS. In addition to a more pronounced activity against malignant cells, we detected decreased tumor volumes and weights in beauvericin-treated mice compared to controls in both the allo- and the xenograft model without any adverse effects. No significant differences were detected concerning percentages of proliferating and mitotic cells in tumor sections from treated and untreated mice. However, a significant increase of necrotic areas within whole tumor sections of beauvericin-treated mice was found in both models corresponding to an enhanced number of TUNEL-positive, i.e., apoptotic, cells. Furthermore, moderate beauvericin accumulation was detected in tumor tissues. In conclusion, we suggest beauvericin as a promising novel natural compound for anticancer therapy.en
dc.identifier.eissn2072-6651
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/10023
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-9014
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc610 Medizin und Gesundheitde
dc.subject.othercyclohexadepsipeptideen
dc.subject.otherbeauvericinen
dc.subject.othercervix carcinomaen
dc.subject.othercolorectal carcinomaen
dc.subject.othertherapyen
dc.titleThe Natural Fungal Metabolite Beauvericin Exerts Anticancer Activity In Vivo: A Pre-Clinical Pilot Studyen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber258en
dcterms.bibliographicCitation.doi10.3390/toxins9090258en
dcterms.bibliographicCitation.issue9en
dcterms.bibliographicCitation.journaltitleToxinsen
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume9en
tub.accessrights.dnbfreeen
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Chemie::FG Biologische Chemiede
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.groupFG Biologische Chemiede
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen

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