Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition‐Metal Catalysts
dc.contributor.author | Seliger, Jan | |
dc.contributor.author | Oestreich, Martin | |
dc.date.accessioned | 2021-02-25T12:09:05Z | |
dc.date.available | 2021-02-25T12:09:05Z | |
dc.date.issued | 2020-10-27 | |
dc.date.updated | 2021-02-22T15:26:02Z | |
dc.description.abstract | A nonenzymatic dynamic kinetic resolution of acyclic and cyclic benzylic alcohols is reported. The approach merges rapid transition‐metal‐catalyzed alcohol racemization and enantioselective Cu‐H‐catalyzed dehydrogenative Si‐O coupling of alcohols and hydrosilanes. The catalytic processes are orthogonal, and the racemization catalyst does not promote any background reactions such as the racemization of the silyl ether and its unselective formation. Often‐used ruthenium half‐sandwich complexes are not suitable but a bifunctional ruthenium pincer complex perfectly fulfills this purpose. By this, enantioselective silylation of racemic alcohol mixtures is achieved in high yields and with good levels of enantioselection. | en |
dc.description.sponsorship | TU Berlin, Open-Access-Mittel – 2020 | en |
dc.identifier.eissn | 1521-3773 | |
dc.identifier.issn | 1433-7851 | |
dc.identifier.uri | https://depositonce.tu-berlin.de/handle/11303/12682 | |
dc.identifier.uri | http://dx.doi.org/10.14279/depositonce-11480 | |
dc.language.iso | en | en |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | en |
dc.subject.ddc | 540 Chemie und zugeordnete Wissenschaften | de |
dc.subject.other | asymmetric catalysis | en |
dc.subject.other | copper | en |
dc.subject.other | dehydrogenative coupling | en |
dc.subject.other | dynamic kinetic resolution | en |
dc.subject.other | silicon | en |
dc.title | Dynamic Kinetic Resolution of Alcohols by Enantioselective Silylation Enabled by Two Orthogonal Transition‐Metal Catalysts | en |
dc.type | Article | en |
dc.type.version | publishedVersion | en |
dcterms.bibliographicCitation.doi | 10.1002/anie.202010484 | en |
dcterms.bibliographicCitation.issue | 1 | en |
dcterms.bibliographicCitation.journaltitle | Angewandte Chemie International Edition | en |
dcterms.bibliographicCitation.originalpublishername | Wiley | en |
dcterms.bibliographicCitation.originalpublisherplace | New York, NY | en |
dcterms.bibliographicCitation.pageend | 251 | en |
dcterms.bibliographicCitation.pagestart | 247 | en |
dcterms.bibliographicCitation.volume | 60 | en |
tub.accessrights.dnb | free | en |
tub.affiliation | Fak. 2 Mathematik und Naturwissenschaften::Inst. Chemie::FG Organische Chemie / Synthese und Katalyse | de |
tub.affiliation.faculty | Fak. 2 Mathematik und Naturwissenschaften | de |
tub.affiliation.group | FG Organische Chemie / Synthese und Katalyse | de |
tub.affiliation.institute | Inst. Chemie | de |
tub.publisher.universityorinstitution | Technische Universität Berlin | en |