dc.contributor.author	Jooss, Andreas
dc.contributor.author	Haberbosch, Linus
dc.contributor.author	Köhn, Arvid
dc.contributor.author	Rönnefarth, Maria
dc.contributor.author	Bathe-Peters, Rouven
dc.contributor.author	Kozarzewski, Leonard
dc.contributor.author	Fleischmann, Robert
dc.contributor.author	Scholz, Michael
dc.contributor.author	Schmidt, Sein
dc.contributor.author	Brandt, Stephan A.
dc.date.accessioned	2019-11-08T09:20:49Z
dc.date.available	2019-11-08T09:20:49Z
dc.date.issued	2019-02-27
dc.date.updated	2019-10-02T05:47:51Z
dc.description.abstract	Background and Objective: Transcranial random noise stimulation (tRNS) is an emerging non-invasive brain stimulation technique to modulate brain function, with previous studies highlighting its considerable benefits in therapeutic stimulation of the motor system. However, high variability of results and bidirectional task-dependent effects limit more widespread clinical application. Task dependency largely results from a lack of understanding of the interaction between externally applied tRNS and the endogenous state of neural activity during stimulation. Hence, the aim of this study was to investigate the task dependency of tRNS-induced neuromodulation in the motor system using a finger-tapping task (FT) versus a go/no-go task (GNG). We hypothesized that the tasks would modulate tRNS’ effects on corticospinal excitability (CSE) and task performance in opposite directions. Methods: Thirty healthy subjects received 10 min of tRNS of the dominant primary motor cortex in a double-blind, sham-controlled study design. tRNS was applied during two well-established tasks tied to diverging brain states. Accordingly, participants were randomly assigned to two equally-sized groups: the first group performed a simple motor training task (FT task), known primarily to increase CSE, while the second group performed an inhibitory control task (go/no-go task) associated with inhibition of CSE. To establish task-dependent effects of tRNS, CSE was evaluated prior to- and after stimulation with navigated transcranial magnetic stimulation. Results: In an ‘activating’ motor task, tRNS during FT significantly facilitated CSE. FT task performance improvements, shown by training-related reductions in intertap intervals and increased number of finger taps, were similar for both tRNS and sham stimulation. In an ‘inhibitory’ motor task, tRNS during GNG left CSE unchanged while inhibitory control was enhanced as shown by slowed reaction times and enhanced task accuracy during and after stimulation. Conclusion: We provide evidence that tRNS-induced neuromodulatory effects are task-dependent and that resulting enhancements are specific to the underlying task-dependent brain state. While mechanisms underlying this effect require further investigation, these findings highlight the potential of tRNS in enhancing task-dependent brain states to modulate human behavior.	en
dc.identifier.eissn	1662-453X
dc.identifier.uri	https://depositonce.tu-berlin.de/handle/11303/10278
dc.identifier.uri	http://dx.doi.org/10.14279/depositonce-9240
dc.language.iso	en	en
dc.rights.uri	https://creativecommons.org/licenses/by/4.0/	en
dc.subject.ddc	610 Medizin und Gesundheit	de
dc.subject.ddc	150 Psychologie	de
dc.subject.other	random noise stimulation	en
dc.subject.other	transcranial electrical stimulation	en
dc.subject.other	task dependency	en
dc.subject.other	finger-tapping task	en
dc.subject.other	go/no-go task	en
dc.subject.other	corticospinal excitability	en
dc.subject.other	neuroplasticity	en
dc.title	Motor Task-Dependent Dissociated Effects of Transcranial Random Noise Stimulation in a Finger-Tapping Task Versus a Go/No-Go Task on Corticospinal Excitability and Task Performance	en
dc.type	Article	en
dc.type.version	publishedVersion	en
dcterms.bibliographicCitation.articlenumber	161	en
dcterms.bibliographicCitation.doi	10.3389/fnins.2019.00161	en
dcterms.bibliographicCitation.journaltitle	Frontiers in Neuroscience	en
dcterms.bibliographicCitation.originalpublishername	Frontiers Media S.A.	en
dcterms.bibliographicCitation.originalpublisherplace	Lausanne	en
dcterms.bibliographicCitation.volume	13	en
tub.accessrights.dnb	free	en
tub.affiliation	Fak. 4 Elektrotechnik und Informatik::Inst. Softwaretechnik und Theoretische Informatik::FG Neuronale Informationsverarbeitung	de
tub.affiliation.faculty	Fak. 4 Elektrotechnik und Informatik	de
tub.affiliation.group	FG Neuronale Informationsverarbeitung	de
tub.affiliation.institute	Inst. Softwaretechnik und Theoretische Informatik	de
tub.publisher.universityorinstitution	Technische Universität Berlin	en

Motor Task-Dependent Dissociated Effects of Transcranial Random Noise Stimulation in a Finger-Tapping Task Versus a Go/No-Go Task on Corticospinal Excitability and Task Performance

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