Potential of Lesion‐to‐Fat Elasticity Ratio Measured by Shear Wave Elastography to Reduce Benign Biopsies in BI‐RADS 4 Breast Lesions

dc.contributor.authorTogawa, Riku
dc.contributor.authorPfob, André
dc.contributor.authorBüsch, Christopher
dc.contributor.authorAlwafai, Zaher
dc.contributor.authorBalleyguier, Corinne
dc.contributor.authorClevert, Dirk‐André
dc.contributor.authorDuda, Volker
dc.contributor.authorFastner, Sarah
dc.contributor.authorGoncalo, Manuela
dc.contributor.authorGomez, Christina
dc.contributor.authorGruber, Ines
dc.contributor.authorHahn, Markus
dc.contributor.authorHennigs, André
dc.contributor.authorKapetas, Panagiotis
dc.contributor.authorNees, Juliane
dc.contributor.authorOhlinger, Ralf
dc.contributor.authorRiedel, Fabian
dc.contributor.authorRutten, Matthieu
dc.contributor.authorSchäfgen, Benedikt
dc.contributor.authorStieber, Anne
dc.contributor.authorTozaki, Mitsuhiro
dc.contributor.authorWojcinski, Sebastian
dc.contributor.authorRauch, Geraldine
dc.contributor.authorHeil, Jörg
dc.contributor.authorBarr, Richard
dc.contributor.authorGolatta, Michael
dc.date.accessioned2023-11-09T12:12:58Z
dc.date.available2023-11-09T12:12:58Z
dc.date.issued2023-02-15
dc.date.updated2023-10-16T08:21:01Z
dc.description.abstractObjectives—We evaluated whether lesion-to-fat ratio measured by shear wave elastography in patients with Breast Imaging Reporting and Data System (BI-RADS) 3 or 4 lesions has the potential to further refine the assessment of B-mode ultrasound alone in breast cancer diagnostics. Methods—This was a secondary analysis of an international diagnostic multicenter trial (NCT02638935). Data from 1288 women with breast lesions categorized as BI-RADS 3 and 4a–c by conventional B-mode ultrasound were analyzed, whereby the focus was placed on differentiating lesions categorized as BI-RADS 3 and BI-RADS 4a. All women underwent shear wave elastography and histopathologic evaluation functioning as reference standard. Reduction of benign biopsies as well as the number of missed malignancies after reclassification using lesion-to-fat ratio measured by shear wave elastography were evaluated. Results—Breast cancer was diagnosed in 368 (28.6%) of 1288 lesions. The assessment with conventional B-mode ultrasound resulted in 53.8% (495 of 1288) pathologically benign lesions categorized as BI-RADS 4 and therefore false positives as well as in 1.39% (6 of 431) undetected malignancies categorized as BI-RADS 3. Additional lesion-to-fat ratio in BI-RADS 4a lesions with a cutoff value of 1.85 resulted in 30.11% biopsies of benign lesions which correspond to a reduction of 44.04% of false positives. Conclusions—Adding lesion-to-fat ratio measured by shear wave elastography to conventional B-mode ultrasound in BI-RADS 4a breast lesions could help reduce the number of benign biopsies by 44.04%. At the same time, however, 1.98% of malignancies were missed, which would still be in line with American College of Radiology BI-RADS 3 definition of <2% of undetected malignancies.en
dc.identifier.eissn1550-9613
dc.identifier.issn0278-4297
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/20273
dc.identifier.urihttps://doi.org/10.14279/depositonce-19071
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject.ddc600 Technik, Medizin, angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit
dc.subject.otherB‐mode ultrasound
dc.subject.otherbiopsy
dc.subject.otherbreast cancer diagnostics
dc.subject.othershear wave elastography
dc.titlePotential of Lesion‐to‐Fat Elasticity Ratio Measured by Shear Wave Elastography to Reduce Benign Biopsies in BI‐RADS 4 Breast Lesionsen
dc.typeArticle
dc.type.versionpublishedVersion
dcterms.bibliographicCitation.doi10.1002/jum.16192
dcterms.bibliographicCitation.issue8
dcterms.bibliographicCitation.journaltitleJournal of Ultrasound in Medicineen
dcterms.bibliographicCitation.originalpublishernameWiley
dcterms.bibliographicCitation.originalpublisherplaceNew York, NY
dcterms.bibliographicCitation.pageend1736
dcterms.bibliographicCitation.pagestart1729
dcterms.bibliographicCitation.volume42
dcterms.rightsHolder.referenceCreative-Commons-Lizenz
tub.accessrights.dnbfree
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Mathematik::N/A (Not Applicable)
tub.publisher.universityorinstitutionTechnische Universität Berlin

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