Coxsackievirus B3—Its Potential as an Oncolytic Virus

dc.contributor.authorGeisler, Anja
dc.contributor.authorHazini, Ahmet
dc.contributor.authorHeimann, Lisanne
dc.contributor.authorKurreck, Jens
dc.contributor.authorFechner, Henry
dc.date.accessioned2021-05-19T06:17:07Z
dc.date.available2021-05-19T06:17:07Z
dc.date.issued2021-04-21
dc.date.updated2021-05-03T15:01:01Z
dc.description.abstractOncolytic virotherapy represents one of the most advanced strategies to treat otherwise untreatable types of cancer. Despite encouraging developments in recent years, the limited fraction of patients responding to therapy has demonstrated the need to search for new suitable viruses. Coxsackievirus B3 (CVB3) is a promising novel candidate with particularly valuable features. Its entry receptor, the coxsackievirus and adenovirus receptor (CAR), and heparan sulfate, which is used for cellular entry by some CVB3 variants, are highly expressed on various cancer types. Consequently, CVB3 has broad anti-tumor activity, as shown in various xenograft and syngeneic mouse tumor models. In addition to direct tumor cell killing the virus induces a strong immune response against the tumor, which contributes to a substantial increase in the efficiency of the treatment. The toxicity of oncolytic CVB3 in healthy tissues is variable and depends on the virus strain. It can be abrogated by genetic engineering the virus with target sites of microRNAs. In this review, we present an overview of the current status of the development of CVB3 as an oncolytic virus and outline which steps still need to be accomplished to develop CVB3 as a therapeutic agent for clinical use in cancer treatment.en
dc.description.sponsorshipDFG, 414044773, Open Access Publizieren 2021 - 2022 / Technische Universität Berlinde
dc.identifier.eissn1999-4915
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/13120
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-11914
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc610 Medizin und Gesundheitde
dc.subject.otherCoxsackievirus B3en
dc.subject.othermicroRNAen
dc.subject.othermiRen
dc.subject.otheroncolytic virusen
dc.subject.othercanceren
dc.subject.othervirus adaptationen
dc.titleCoxsackievirus B3—Its Potential as an Oncolytic Virusen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber718en
dcterms.bibliographicCitation.doi10.3390/v13050718en
dcterms.bibliographicCitation.issue5en
dcterms.bibliographicCitation.journaltitleVirusesen
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume13en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften>Inst. Biotechnologie>FG Angewandte Biochemiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Angewandte Biochemiede
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
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