Involvement of secondary metabolites in the pathogenesis of the American foulbrood of honey bees caused by Paenibacillus larvae

dc.contributor.authorMüller, Sebastian
dc.contributor.authorGarcía-Gonzalez, Eva
dc.contributor.authorGenersch, Elke
dc.contributor.authorSüßmuth, Roderich D.
dc.date.accessioned2017-10-25T06:27:25Z
dc.date.available2017-10-25T06:27:25Z
dc.date.issued2015
dc.description.abstractCovering: 2011 to end of 2014 The Gram-positive, spore-forming bacterium Paenibacillus larvae (P. larvae) is the causative agent of the epizootic American Foulbrood (AFB), a fatal brood disease of the western honey bee (Apis mellifera). AFB is one of the most destructive honey bee diseases since it is not only lethal for infected larvae but also for the diseased colonies. Due to the high impact of honey bees on ecology and economy this epizootic is a severe and pressing problem. Knowledge about virulence mechanisms and the underlying molecular mechanisms remain largely elusive. Recent genome sequencing of P. larvae revealed its potential to produce unknown secondary metabolites, like nonribosomal peptides and peptide-polyketide hybrids. This article highlights recent findings on secondary metabolites synthesized by P. larvae and discusses their role in virulence and pathogenicity towards the bee larvae.en
dc.identifier.eissn1460-4752
dc.identifier.issn0265-0568
dc.identifier.pmid25904391
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/6955
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-6294
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.titleInvolvement of secondary metabolites in the pathogenesis of the American foulbrood of honey bees caused by Paenibacillus larvaeen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1039/c4np00158c
dcterms.bibliographicCitation.issue6
dcterms.bibliographicCitation.journaltitleNatural product reportsen
dcterms.bibliographicCitation.originalpublishernameRoyal Society of Chemistryde
dcterms.bibliographicCitation.originalpublisherplaceCambridgede
dcterms.bibliographicCitation.pageend778
dcterms.bibliographicCitation.pagestart765
dcterms.bibliographicCitation.volume32
tub.accessrights.dnbfree
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Chemie::FG Organische Chemiede
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.groupFG Organische Chemiede
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlin

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