Graphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applications

dc.contributor.authorMansuriya, Bhargav D.
dc.contributor.authorAltintas, Zeynep
dc.date.accessioned2020-02-17T13:37:26Z
dc.date.available2020-02-17T13:37:26Z
dc.date.issued2019-12-23
dc.description.abstractIn the area of biomedicine, research for designing electrochemical sensors has evolved over the past decade, since it is crucial to selectively quantify biomarkers or pathogens in clinical samples for the efficacious diagnosis and/or treatment of various diseases. To fulfil the demand of rapid, specific, economic, and easy detection of such biomolecules in ultralow amounts, numerous nanomaterials have been explored to effectively enhance the sensitivity, selectivity, and reproducibility of immunosensors. Graphene quantum dots (GQDs) have garnered tremendous attention in immunosensor development, owing to their special attributes such as large surface area, excellent biocompatibility, quantum confinement, edge effects, and abundant sites for chemical modification. Besides these distinct features, GQDs acquire peroxidase (POD)-mimicking electro-catalytic activity, and hence, they can replace horseradish peroxidase (HRP)-based systems to conduct facile, quick, and inexpensive label-free immunoassays. The chief motive of this review article is to summarize and focus on the recent advances in GQD-based electrochemical immunosensors for the early and rapid detection of cancer, cardiovascular disorders, and pathogenic diseases. Moreover, the underlying principles of electrochemical immunosensing techniques are also highlighted. These GQD immunosensors are ubiquitous in biomedical diagnosis and conducive for miniaturization, encouraging low-cost disease diagnostics in developing nations using point-of-care testing (POCT) and similar allusive techniques.en
dc.description.sponsorshipTU Berlin, Open-Access-Mittel - 2019en
dc.identifier.eissn1996-1944
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/10794
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-9690
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc600 Technik, Technologiede
dc.subject.othergraphene quantum dotsen
dc.subject.otherGQDsen
dc.subject.othernanomaterialsen
dc.subject.otherelectrochemical immunosensorsen
dc.subject.othercancer diagnosisen
dc.subject.otherinfectious diseasesen
dc.subject.othercardiovascular disordersen
dc.titleGraphene Quantum Dot-Based Electrochemical Immunosensors for Biomedical Applicationsen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber96en
dcterms.bibliographicCitation.doi10.3390/ma13010096en
dcterms.bibliographicCitation.issue1en
dcterms.bibliographicCitation.journaltitleMaterialsen
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume13en
tub.accessrights.dnbfreeen
tub.affiliationFak. 2 Mathematik und Naturwissenschaften>Inst. Chemie>FG Technische Chemiede
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.groupFG Technische Chemiede
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen
Files
Original bundle
Now showing 1 - 1 of 1
Loading…
Thumbnail Image
Name:
materials-13-00096-v2.pdf
Size:
3.33 MB
Format:
Adobe Portable Document Format
Description:
Collections