Liver fat scores do not reflect interventional changes in liver fat content induced by high-protein diets

dc.contributor.authorKabisch, Stefan
dc.contributor.authorMarkova, Mariya
dc.contributor.authorHornemann, Silke
dc.contributor.authorSucher, Stephanie
dc.contributor.authorPivovarova-Ramich, Olga
dc.contributor.authorMachann, Jürgen
dc.contributor.authorHierholzer, Johannes
dc.contributor.authorRohn, Sascha
dc.contributor.authorPfeiffer, Andreas F. H.
dc.date.accessioned2023-04-19T12:50:16Z
dc.date.available2023-04-19T12:50:16Z
dc.date.issued2021-04-23
dc.date.updated2023-03-27T22:50:09Z
dc.description.abstractNon-alcoholic fatty liver disease (NAFLD) is common in Metabolic Syndrome and type 2 diabetes (T2DM), driven by energy imbalance, saturated fats and simple carbohydrates. NAFLD requires screening and monitoring for late complications. Liver fat indices may predict NAFLD avoiding expensive or invasive gold-standard methods, but they are poorly validated for use in interventional settings. Recent data indicate a particular insensitivity to weight-independent liver fat reduction. We evaluated 31 T2DM patients, completing a randomized intervention study on isocaloric high-protein diets. We assessed anthropometric measures, intrahepatic lipid (IHL) content and serum liver enzymes, allowing AUROC calculations as well as cross-sectional and longitudinal Spearman correlations between the fatty liver index, the NAFLD-liver fat score, the Hepatosteatosis Index, and IHL. At baseline, all indices predicted NAFLD with moderate accuracy (AUROC 0.731–0.770), supported by correlation analyses. Diet-induced IHL changes weakly correlated with changes of waist circumference, but no other index component or the indices themselves. Liver fat indices may help to easily detect NAFLD, allowing cost-effective allocation of further diagnostics to patients at high risk. IHL reduction by weight-independent diets is not reflected by a proportional change in liver fat scores. Further research on the development of treatment-sensitive indices is required. Trial registration: The trial was registered at clinicaltrials.gov: NCT02402985.en
dc.identifier.eissn2045-2322
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/18613
dc.identifier.urihttps://doi.org/10.14279/depositonce-17422
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subject.ddc500 Naturwissenschaften und Mathematik::540 Chemie::540 Chemie und zugeordnete Wissenschaften
dc.subject.otherendocrine system and metabolic diseasesen
dc.subject.othergastrointestinal diseasesen
dc.subject.othermetabolic disordersen
dc.subject.othernutrition disordersen
dc.titleLiver fat scores do not reflect interventional changes in liver fat content induced by high-protein dietsen
dc.typeArticle
dc.type.versionpublishedVersion
dcterms.bibliographicCitation.articlenumber8843
dcterms.bibliographicCitation.doi10.1038/s41598-021-87360-2
dcterms.bibliographicCitation.issue1
dcterms.bibliographicCitation.journaltitleScientific Reports
dcterms.bibliographicCitation.originalpublishernameSpringer Nature
dcterms.bibliographicCitation.originalpublisherplaceHeidelberg
dcterms.bibliographicCitation.volume11
dcterms.rightsHolder.referenceCreative-Commons-Lizenz
tub.accessrights.dnbfree
tub.affiliationFak. 3 Prozesswissenschaften::Inst. Lebensmitteltechnologie und Lebensmittelchemie::FG Lebensmittelchemie und Analytik
tub.publisher.universityorinstitutionTechnische Universität Berlin

Files

Original bundle
Now showing 1 - 1 of 1
Loading…
Thumbnail Image
Name:
s41598-021-87360-2.pdf
Size:
1020.63 KB
Format:
Adobe Portable Document Format
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.86 KB
Format:
Item-specific license agreed upon to submission
Description:

Collections