Development and Testing of an LED-Based Near-Infrared Sensor for Human Kidney Tumor Diagnostics

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dc.contributor.authorBogomolov, Andrey
dc.contributor.authorZabarylo, Urszula
dc.contributor.authorKirsanov, Dmitry
dc.contributor.authorBelikova, Valeria
dc.contributor.authorAgeev, Vladimir
dc.contributor.authorUsenov, Iskander
dc.contributor.authorGalyanin, Vladislav
dc.contributor.authorMinet, Olaf
dc.contributor.authorSakharova, Tatiana
dc.contributor.authorDanielyan, Georgy
dc.contributor.authorFeliksberger, Elena
dc.contributor.authorArtyushenko, Viacheslav
dc.date.accessioned2019-08-23T08:59:02Z
dc.date.available2019-08-23T08:59:02Z
dc.date.issued2017-08-19
dc.date.updated2019-08-01T10:14:44Z
dc.description.abstractOptical spectroscopy is increasingly used for cancer diagnostics. Tumor detection feasibility in human kidney samples using mid- and near-infrared (NIR) spectroscopy, fluorescence spectroscopy, and Raman spectroscopy has been reported (Artyushenko et al., Spectral fiber sensors for cancer diagnostics in vitro. In Proceedings of the European Conference on Biomedical Optics, Munich, Germany, 21–25 June 2015). In the present work, a simplification of the NIR spectroscopic analysis for cancer diagnostics was studied. The conventional high-resolution NIR spectroscopic method of kidney tumor diagnostics was replaced by a compact optical sensing device constructively represented by a set of four light-emitting diodes (LEDs) at selected wavelengths and one detecting photodiode. Two sensor prototypes were tested using 14 in vitro clinical samples of 7 different patients. Statistical data evaluation using principal component analysis (PCA) and partial least-squares discriminant analysis (PLS-DA) confirmed the general applicability of the LED-based sensing approach to kidney tumor detection. An additional validation of the results was performed by means of sample permutation.en
dc.identifier.eissn1424-8220
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/9869
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-8881
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc610 Medizin und Gesundheitde
dc.subject.ddc530 Physikde
dc.subject.othertumor detectionen
dc.subject.otherkidneyen
dc.subject.otherfiber spectroscopyen
dc.subject.otheroptical sensoren
dc.subject.othernear infrareden
dc.subject.otherLEDen
dc.titleDevelopment and Testing of an LED-Based Near-Infrared Sensor for Human Kidney Tumor Diagnosticsen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber1914en
dcterms.bibliographicCitation.doi10.3390/s17081914en
dcterms.bibliographicCitation.issue8en
dcterms.bibliographicCitation.journaltitleSensorsen
dcterms.bibliographicCitation.originalpublishernameMDPIen
dcterms.bibliographicCitation.originalpublisherplaceBaselen
dcterms.bibliographicCitation.volume17en
tub.accessrights.dnbfreeen
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Optik und Atomare Physik::FG Nichtlineare Optikde
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.groupFG Nichtlineare Optikde
tub.affiliation.instituteInst. Optik und Atomare Physikde
tub.publisher.universityorinstitutionTechnische Universität Berlinen

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