Defunctionalisation catalysed by boron Lewis acids
| dc.contributor.author | Fang, Huaquan | |
| dc.contributor.author | Oestreich, Martin | |
| dc.date.accessioned | 2021-01-14T12:40:57Z | |
| dc.date.available | 2021-01-14T12:40:57Z | |
| dc.date.issued | 2020-07-28 | |
| dc.description.abstract | Selective defunctionalisation of organic molecules to valuable intermediates is a fundamentally important transformation in organic synthesis. Despite the advances made in efficient and selective defunctionalisation using transition-metal catalysis, the cost, toxicity, and non-renewable properties limit its application in industrial manufacturing processes. In this regard, boron Lewis acid catalysis has emerged as a powerful tool for the cleavage of carbon–heteroatom bonds. The ground-breaking finding is that the strong boron Lewis acid B(C6F5)3 can activate Si–H bonds through η1 coordination, and this Lewis adduct is a key intermediate that enables various reduction processes. This system can be tuned by variation of the electronic and structural properties of the borane catalyst, and together with different hydride sources high chemoselectivity can be achieved. This Perspective provides a comprehensive summary of various defunctionalisation reactions such as deoxygenation, decarbonylation, desulfurisation, deamination, and dehalogenation, all of which catalysed by boron Lewis acids. | en |
| dc.identifier.eissn | 2041-6539 | |
| dc.identifier.issn | 2041-6520 | |
| dc.identifier.uri | https://depositonce.tu-berlin.de/handle/11303/12445 | |
| dc.identifier.uri | http://dx.doi.org/10.14279/depositonce-11287 | |
| dc.language.iso | en | en |
| dc.rights.uri | https://creativecommons.org/licenses/by/3.0/ | en |
| dc.subject.ddc | 540 Chemie und zugeordnete Wissenschaften | de |
| dc.subject.other | boron Lewis acids | en |
| dc.subject.other | defunctionalisation | en |
| dc.subject.other | organic synthesis | en |
| dc.title | Defunctionalisation catalysed by boron Lewis acids | en |
| dc.type | Article | en |
| dc.type.version | publishedVersion | en |
| dcterms.bibliographicCitation.doi | 10.1039/D0SC03712E | en |
| dcterms.bibliographicCitation.issue | 47 | en |
| dcterms.bibliographicCitation.journaltitle | Chemical Science | en |
| dcterms.bibliographicCitation.originalpublishername | Royal Society of Chemistry | en |
| dcterms.bibliographicCitation.originalpublisherplace | Cambridge | en |
| dcterms.bibliographicCitation.pageend | 12615 | en |
| dcterms.bibliographicCitation.pagestart | 12604 | en |
| dcterms.bibliographicCitation.volume | 11 | en |
| tub.accessrights.dnb | free | en |
| tub.affiliation | Fak. 2 Mathematik und Naturwissenschaften::Inst. Chemie::FG Organische Chemie / Synthese und Katalyse | de |
| tub.affiliation.faculty | Fak. 2 Mathematik und Naturwissenschaften | de |
| tub.affiliation.group | FG Organische Chemie / Synthese und Katalyse | de |
| tub.affiliation.institute | Inst. Chemie | de |
| tub.publisher.universityorinstitution | Technische Universität Berlin | en |