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Tailored silica coated Ag nanoparticles for non-invasive surface enhanced Raman spectroscopy of biomolecular targets

Sivanesan, Arumugam; Kozuch, Jacek; Ly, Hoang Khoa; Kalaivani, Govindasamy; Fischer, Anna; Weidinger, Inez M.

Silica coated Ag nanoparticles with defined surface plasmon resonances are used to selectively detect and analyze protein cofactors in solution and on interfaces via surface enhanced resonance Raman spectroscopy. The silica coating has a surprisingly small effect on optical amplification but minimizes unwanted interactions between the protein and the nanoparticle.
Published in: RSC Advances : an international journal to further the chemical sciences, 10.1039/c1ra00781e, Royal Society of Chemistry
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  • This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.