Hepatitis E virus superinfection and clinical progression in hepatitis B patients

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dc.contributor.authorHoan, Nghiem Xuan
dc.contributor.authorTong, Hoang Van
dc.contributor.authorHecht, Nicole
dc.contributor.authorSy, Bui Tien
dc.contributor.authorMarcinek, Patrick
dc.contributor.authorMeyer, Christian G.
dc.contributor.authorSong, Le Huu
dc.contributor.authorToan, Nguyen Linh
dc.contributor.authorKurreck, Jens
dc.contributor.authorKremsner, Peter G.
dc.contributor.authorBock, C-Thomas
dc.contributor.authorVelavan, Thirumalaisamy P.
dc.date.accessioned2018-05-28T07:56:32Z
dc.date.available2018-05-28T07:56:32Z
dc.date.issued2015
dc.description.abstractHepatitis E virus (HEV) infection may cause acute hepatitis and lead to hepatic failure in developing and developed countries. We studied HEV seroprevalences in patients with hepatitis B virus (HBV) infection to understand the consequences of HEV superinfection in a Vietnamese population. This cross-sectional study was conducted from 2012 to 2013 and included 1318 Vietnamese patients with HBV-related liver diseases and 340 healthy controls. The case group included patients with acute (n = 26) and chronic hepatitis B (n = 744), liver cirrhosis (n = 160), hepatocellular carcinoma (n = 166) and patients with both liver cirrhosis and hepatocellular carcinoma (n = 222). Anti-HEV IgG and IgM antibodies were assessed in patients and controls by ELISA. HEV-RNA was identified by PCR assays and sequencing. Seroprevalences of anti-HEV IgG among hepatitis B patients and controls were 45% and 31%, respectively (adjusted P = 0.034). Anti-HEV IgM seroprevalences were 11.6% and 4.7% in patients and controls, respectively (adjusted P = 0.005). Seroprevalences were higher among the elder individuals. When stratifying for patient groups, those with liver cirrhosis had the highest anti-HEV IgG (52%) and anti-HEV IgM (19%) seroprevalences. Hepatitis B patients with current HEV infection had abnormal liver function tests compared to patients with past or without HEV infection. One HEV isolate was retrieved from a patient with both liver cirrhosis and hepatocellular carcinoma and identified as HEV genotype 3. This study indicates high prevalences of HEV infection in Vietnamese HBV patients and among healthy individuals and shows that HEV superinfection may influence the outcome and progression of HBV-related liver disease.en
dc.identifier.issn2352-3964
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/7849
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-7009
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subject.ddc570 Biowissenschaften; Biologiede
dc.subject.otherhepatitis E virusen
dc.subject.otherHEV seroprevalenceen
dc.subject.otherHEV superinfectionen
dc.subject.otherHBV infectionen
dc.subject.otherHBV-related liver diseasesen
dc.titleHepatitis E virus superinfection and clinical progression in hepatitis B patientsen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1016/j.ebiom.2015.11.020en
dcterms.bibliographicCitation.issue12en
dcterms.bibliographicCitation.journaltitleEbiomedicineen
dcterms.bibliographicCitation.originalpublishernameElsevieren
dcterms.bibliographicCitation.originalpublisherplaceAmsterdamen
dcterms.bibliographicCitation.pageend2086en
dcterms.bibliographicCitation.pagestart2080en
dcterms.bibliographicCitation.volume2en
tub.accessrights.dnbfreeen
tub.affiliationFak. 3 Prozesswissenschaften::Inst. Biotechnologie::FG Angewandte Biochemiede
tub.affiliation.facultyFak. 3 Prozesswissenschaftende
tub.affiliation.groupFG Angewandte Biochemiede
tub.affiliation.instituteInst. Biotechnologiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen

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