Recent advances in the field of bioactive tetronates

dc.contributor.authorVieweg, Laura
dc.contributor.authorReichau, Sebastian
dc.contributor.authorSchobert, Rainer
dc.contributor.authorLeadlay, Peter F.
dc.contributor.authorSüßmuth, Roderich D.
dc.date.accessioned2016-06-22T08:05:24Z
dc.date.available2016-06-22T08:05:24Z
dc.date.issued2014
dc.description.abstractCovering: up to mid-2014 Over the last several decades, the number of pharmacologically active natural products has significantly increased and several natural product families have taken shape. This review highlights the family of tetronate and spirotetronate compounds, which show a vast structural and functional diversity. The rapid growth of this group has created the need for a comprehensive overview and classification system, which we have devised based on structural characteristics. An updated overview is provided based on known tetronates, intended to spur further research in this field by identifying common structural features and general principles of their biosynthesis. We also compare a selection of chemical syntheses of representative compounds belonging to individual subtypes, both in terms of their efficiency as well as the extent to which they are biomimetic. This review also summarizes progress in unraveling some of the principles underlying the potent and varied bioactivities of natural tetronate antibiotics, and in identifying and better understanding their structure–activity relationships and modes of action.en
dc.description.sponsorshipDFG, EXC 314, Unifying Concepts in Catalysisen
dc.identifier.eissn0265-0568
dc.identifier.pmid24965099
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/5586
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-5215
dc.language.isoen
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.titleRecent advances in the field of bioactive tetronatesen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1039/c4np00015c
dcterms.bibliographicCitation.issue11
dcterms.bibliographicCitation.journaltitleNatural product reportsen
dcterms.bibliographicCitation.originalpublishernameRoyal Society of Chemistryde
dcterms.bibliographicCitation.originalpublisherplaceCambridgede
dcterms.bibliographicCitation.pageend1584
dcterms.bibliographicCitation.pagestart1554
dcterms.bibliographicCitation.volume31
tub.accessrights.dnbfree
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Chemiede
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlin

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