Three-dimensional quantitative photoacoustic tomography using an adjoint radiance Monte Carlo model and gradient descent

dc.contributor.authorBuchmann, Jens
dc.contributor.authorKaplan, Bernhard A.
dc.contributor.authorPowell, Samuel
dc.contributor.authorProhaska, Steffen
dc.contributor.authorLaufer, Jan
dc.date.accessioned2021-03-04T08:28:00Z
dc.date.available2021-03-04T08:28:00Z
dc.date.issued2019-06-06
dc.description.abstractQuantitative photoacoustic tomography aims to recover maps of the local concentrations of tissue chromophores from multispectral images. While model-based inversion schemes are promising approaches, major challenges to their practical implementation include the unknown fluence distribution and the scale of the inverse problem. We describe an inversion scheme based on a radiance Monte Carlo model and an adjoint-assisted gradient optimization that incorporates fluence-dependent step sizes and adaptive moment estimation. The inversion is shown to recover absolute chromophore concentrations, blood oxygen saturation, and the Grüneisen parameter from in silico three-dimensional phantom images for different radiance approximations. The scattering coefficient is assumed to be homogeneous and known a priori.en
dc.identifier.eissn1560-2281
dc.identifier.issn1083-3668
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/12703
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-11503
dc.language.isoenen
dc.relation.ispartof10.14279/depositonce-10528
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc530 Physikde
dc.subject.otherquantitative photoacoustic imagingen
dc.subject.otherblood oxygen saturationen
dc.subject.otherinverse problemen
dc.subject.othermodel based inversionen
dc.subject.otherMonte Carloen
dc.subject.otherspectral unmixingen
dc.titleThree-dimensional quantitative photoacoustic tomography using an adjoint radiance Monte Carlo model and gradient descenten
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber066001en
dcterms.bibliographicCitation.doi10.1117/1.JBO.24.6.066001en
dcterms.bibliographicCitation.issue6en
dcterms.bibliographicCitation.journaltitleJournal of Biomedical Opticsen
dcterms.bibliographicCitation.originalpublishernameSPIEen
dcterms.bibliographicCitation.originalpublisherplaceBellingham, Wash.en
dcterms.bibliographicCitation.volume24en
tub.accessrights.dnbfreeen
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Optik und Atomare Physikde
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.instituteInst. Optik und Atomare Physikde
tub.publisher.universityorinstitutionTechnische Universität Berlinen

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