Temperature-induced molecular transport through polymer multilayers coated with PNIPAM microgels

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dc.contributor.authorVikulina, Anna S.
dc.contributor.authorAleed, Sarah T.
dc.contributor.authorPaulraj, Thomas
dc.contributor.authorVladimirov, Yury Andreevich
dc.contributor.authorDuschl, Claus
dc.contributor.authorKlitzing, Regine von
dc.contributor.authorVolodkin, Dmitry
dc.date.accessioned2017-10-25T06:27:31Z
dc.date.available2017-10-25T06:27:31Z
dc.date.issued2015
dc.descriptionDieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG geförderten) Allianz- bzw. Nationallizenz frei zugänglich.de
dc.descriptionThis publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.en
dc.description.abstractPolyelectrolyte multilayers serve as effective reservoirs for bioactive molecules which are stored and released from the multilayers for cellular applications. However, control over the release without significantly affecting the multilayers and biomolecules is still a challenge. On the other hand, externally stimulated release would make the multilayers promising for the development of stimuli-sensitive planar carriers with release performance switched on demand. In this study soft composite films are designed by coating hyaluronic acid/poly-L-lysine (HA/PLL) multilayers with temperature responsive poly( N-isopropylacrylamide) (PNIPAM) microgels. Microgels are flattened and immersed into the multilayers to maximize the number of contacts with the surrounding polyelectrolytes (HA and PLL). The microgel coating serves as an efficient switchable barrier for the PLL transport into the multilayers. PLL diffusion into the film is significantly hindered at room temperature but is dramatically enhanced at 40 degrees C above the volume phase transition temperature (VPTT) of PNIPAM at 32 degrees C associated with microgel shrinkage. Scanning force microscopy micrographs show that the mechanism of volume phase transition on soft surfaces cannot be directly deduced from the processes taking place at solid substrates.en
dc.identifier.eissn1463-9084
dc.identifier.issn1463-9076
dc.identifier.pmid25906292
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/6958
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-6297
dc.language.isoen
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.subject.ddc540 Chemie und zugeordnete Wissenschaftende
dc.titleTemperature-induced molecular transport through polymer multilayers coated with PNIPAM microgelsen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.doi10.1039/c5cp01213a
dcterms.bibliographicCitation.issue19
dcterms.bibliographicCitation.journaltitlePhysical chemistry, chemical physicsen
dcterms.bibliographicCitation.originalpublishernameRoyal Society of Chemistryde
dcterms.bibliographicCitation.originalpublisherplaceCambridgede
dcterms.bibliographicCitation.pageend12777
dcterms.bibliographicCitation.pagestart12771
dcterms.bibliographicCitation.volume17
tub.accessrights.dnbdomain
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Chemiede
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlin

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