Facile Control over the Supramolecular Ordering of Selfassembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharride

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dc.contributor.authorLi, Rui
dc.contributor.authorBoyd-Moss, Mitchell
dc.contributor.authorLong, Benjamin
dc.contributor.authorMartel, Anne
dc.contributor.authorParnell, Andrew
dc.contributor.authorDennison, Andrew J. C.
dc.contributor.authorBarrow, Colin J.
dc.contributor.authorNisbet, David R.
dc.contributor.authorWilliams, Richard J.
dc.date.accessioned2018-06-14T09:35:33Z
dc.date.available2018-06-14T09:35:33Z
dc.date.issued2017-07-06
dc.description.abstractEnabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly.en
dc.identifier.issn2045-2322
dc.identifier.urihttps://depositonce.tu-berlin.de/handle/11303/7939
dc.identifier.urihttp://dx.doi.org/10.14279/depositonce-7101
dc.language.isoenen
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subject.ddc500 Naturwissenschaften und Mathematikde
dc.subject.ddc600 Technik, Technologiede
dc.subject.otherbiomaterial engineeringen
dc.subject.othercontrol over macromolecular orderingen
dc.subject.otherself-assembly of minimalist peptidesen
dc.subject.otherFmoc-FRGDF peptideen
dc.titleFacile Control over the Supramolecular Ordering of Selfassembled Peptide Scaffolds by Simultaneous Assembly with a Polysacharrideen
dc.typeArticleen
dc.type.versionpublishedVersionen
dcterms.bibliographicCitation.articlenumber4797en
dcterms.bibliographicCitation.doi10.1038/s41598-017-04643-3en
dcterms.bibliographicCitation.journaltitleScientific Reportsen
dcterms.bibliographicCitation.originalpublishernameMacmillan Publishers Limited, part of Springer Natureen
dcterms.bibliographicCitation.originalpublisherplace[London]en
dcterms.bibliographicCitation.pageend8en
dcterms.bibliographicCitation.pagestart1en
dcterms.bibliographicCitation.volume7en
tub.accessrights.dnbfreeen
tub.affiliationFak. 2 Mathematik und Naturwissenschaften::Inst. Chemie::FG Physikalische Chemie / Molekulare Materialwissenschaftende
tub.affiliation.facultyFak. 2 Mathematik und Naturwissenschaftende
tub.affiliation.groupFG Physikalische Chemie / Molekulare Materialwissenschaftende
tub.affiliation.instituteInst. Chemiede
tub.publisher.universityorinstitutionTechnische Universität Berlinen

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