Introduction of Substituents on the 2-Oxo-piperazine Skeleton by [3+2] Cycloaddition and Subsequent Transformation

Wierschem, FrankRück-Braun, Karola2018-10-152018-10-1520060932-0776https://depositonce.tu-berlin.de/handle/11303/8340http://dx.doi.org/10.14279/depositonce-7492The 3,4-substituted 2-oxo-piperazines 5 - 9 are obtained by [3+2] cycloaddition from nitrone 1 and a variety of alkenes. Subsequent functionalization of the bicyclic adducts involves reductive N-O bond cleavage. A route towards libraries of immobilized 1,3-aminoalcohols with a 3,4-substituted 2-oxo-piperazine scaffold is briefly discussed for adducts derived from N-substituted maleic imidesen540 Chemie und zugeordnete Wissenschaften2-Oxo-piperazineScaffold[3+2] CycloadditionNitroneN-O bond cleavageIntroduction of Substituents on the 2-Oxo-piperazine Skeleton by [3+2] Cycloaddition and Subsequent TransformationArticle1865-7117