Li, RuiBoyd-Moss, MitchellLong, BenjaminMartel, AnneParnell, AndrewDennison, Andrew J. C.Barrow, Colin J.Nisbet, David R.Williams, Richard J.2018-06-142018-06-142017-07-062045-2322https://depositonce.tu-berlin.de/handle/11303/7939http://dx.doi.org/10.14279/depositonce-7101Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly.en500 Naturwissenschaften und Mathematik600 Technik, Technologiebiomaterial engineeringcontrol over macromolecular orderingself-assembly of minimalist peptidesFmoc-FRGDF peptideArticle