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Nickel‐Catalyzed, Reductive C(sp3)−Si Cross‐Coupling of α‐Cyano Alkyl Electrophiles and Chlorosilanes

Zhang, Liangliang; Oestreich, Martin

A nickel/zinc‐catalyzed cross‐electrophile coupling of alkyl electrophiles activated by an α‐cyano group and chlorosilanes is reported. Elemental zinc is the stoichiometric reductant in this reductive coupling process. By this, a C(sp3)−Si bond can be formed starting from two electrophilic reactants whereas previous methods rely on the combination of carbon nucleophiles and silicon electrophiles or vice versa.
Published in: Angewandte Chemie International Edition, 10.1002/anie.202107492, Wiley