A 2,7-dichlorofluorescein derivative to monitor microcalcifications
| dc.contributor.author | Tholen, Patrik | |
| dc.contributor.author | Brown, Connor N. | |
| dc.contributor.author | Keil, Claudia | |
| dc.contributor.author | Bayir, Ali | |
| dc.contributor.author | Zeng , Hui-Hui | |
| dc.contributor.author | Haase, Hajo | |
| dc.contributor.author | Thompson, Richard B. | |
| dc.contributor.author | Lengyel, Imre | |
| dc.contributor.author | Yücesan, Gündoğ | |
| dc.date.accessioned | 2022-12-13T15:11:51Z | |
| dc.date.available | 2022-12-13T15:11:51Z | |
| dc.date.issued | 2022-10-10 | |
| dc.description.abstract | Herein, we report the crystal structure of 2,7-dichlorofluorescein methyl ester (DCF-ME) and its fluorescence response to hydroxyapatite binding. The reported fluorophore is very selective for staining the bone matrix and provides turn-on fluorescence upon hydroxyapatite binding. The reported fluorophore can readily pass the cell membrane of the C2C12 cell line, and it is non-toxic for the cell line. The reported fluorophore DCF-ME may find applications in monitoring bone remodeling and microcalcification as an early diagnosis tool for breast cancer and age-related macular degeneration. | en |
| dc.description.sponsorship | TU Berlin, Open-Access-Mittel – 2022 | |
| dc.identifier.eissn | 2058-9689 | |
| dc.identifier.uri | https://depositonce.tu-berlin.de/handle/11303/17797 | |
| dc.identifier.uri | https://doi.org/10.14279/depositonce-16586 | |
| dc.language.iso | en | |
| dc.relation.issupplementedby | 10.1039/d2me00185c | |
| dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
| dc.subject.ddc | 540 Chemie und zugeordnete Wissenschaften | de |
| dc.subject.other | breast cancer | en |
| dc.subject.other | fluorophore | en |
| dc.subject.other | cell membrane | en |
| dc.subject.other | bone morphogenetic protein-2 | en |
| dc.subject.other | DCF-ME | en |
| dc.title | A 2,7-dichlorofluorescein derivative to monitor microcalcifications | |
| dc.type | Article | |
| dc.type.version | publishedVersion | |
| dcterms.bibliographicCitation.doi | 10.1039/D2ME00185C | |
| dcterms.bibliographicCitation.issue | 11 | |
| dcterms.bibliographicCitation.journaltitle | Molecular Systems Design & Engineering | |
| dcterms.bibliographicCitation.originalpublishername | Royal Society of Chemistry (RSC) | |
| dcterms.bibliographicCitation.originalpublisherplace | Cambridge | |
| dcterms.bibliographicCitation.pageend | 1421 | |
| dcterms.bibliographicCitation.pagestart | 1415 | |
| dcterms.bibliographicCitation.volume | 7 | |
| oaire.citation.issue | 11 | |
| oaire.citation.volume | 7 | |
| tub.accessrights.dnb | free | * |
| tub.affiliation | Fak. 3 Prozesswissenschaften::Inst. Lebensmitteltechnologie und Lebensmittelchemie::FG Lebensmittelchemie und Toxikologie | |
| tub.publisher.universityorinstitution | Technische Universität Berlin |